172832-10-9

Basic information

• Product Name: 9-Methoxy-2,3,4,5-tetrahydro[1]benzothieno[2,3-f]-1,4-thiazepin-5-one
• Synonyms: PD-146626
• CAS NO: 172832-10-9
• Molecular Formula: C₁₂H₁₁NO₂S₂
• Molecular Weight: 265.35497
• Mol File: 172832-10-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 9-Methoxy-2,3,4,5-tetrahydro[1]benzothieno[2,3-f]-1,4-thiazepin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Methoxy-2,3,4,5-tetrahydro[1]benzothieno[2,3-f]-1,4-thiazepin-5-one(172832-10-9)
• EPA Substance Registry System: 9-Methoxy-2,3,4,5-tetrahydro[1]benzothieno[2,3-f]-1,4-thiazepin-5-one(172832-10-9)

Safety Data

• Hazardous Substances Data: 172832-10-9(Hazardous Substances Data)

Upstream product

• 14755-02-3 3-hydroxy-trans-cinnamic acid 
• 122024-75-3 3-<3-(phenylmethoxy)phenyl>-2-propenoic acid 
• 122024-71-9 3-Chloro-5-(phenylmethoxy)-benzo[b]thiophene-2-carbonyl chloride 
• 14755-02-3 3-hydroxycinnamic acid 
• 1233533-04-4 kb-NB142-70 
• 74-88-4 methyl iodide 
• 1259977-97-3 kb-NB₁₂₃-66 
• 1259977-93-9 methyl 5-(benzyloxy)-3-chlorobenzo[b]thiophene-2-carboxylate 
• 122024-75-3 C₁₆H₁₄O₃ 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 41280-81-3 methyl 3-chloro-5-methoxybenzo[b]thiophene-2-carboxylate 
• 60-23-1 Cysteamine 

Relevant articles and documents

PROTEIN KINASE D INHIBITORS

Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription, and protein trafficking. Accordingly, pharmaceutically acceptable compositions of the inventive compounds are candidate therapeutics for pathological conditions conditioned by changes in PKD activity.

Benzothiophene inhibitors of MK2. Part 1: Structure-activity relationships, assessments of selectivity and cellular potency

Identification of potent benzothiophene inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2), structure-activity relationship (SAR) studies, selectivity assessments against CDK2, cellular potency and mechanism of action are pres

Methods for inhibiting and controlling viral growth

Benzothiophene, benzofuran and indolethiazepinones, oxazepinones, and diazepinones are effective therapeutic agents for treating viral diseases, including those caused by herpesvirus and HIV.