17288-52-7Relevant articles and documents
Coexistence of an antiferromagnetically coupled dimer and isolated paramagnetic spin in 4-azaindol-2-yl nitronyl nitroxide crystal
Nagashima, Hideaki,Hashimoto, Noriko,Inoue, Hidenari,Yoshioka, Naoki
, p. 805 - 810 (2003)
A novel stable organic radical, 2-(4-azaindol-2-yl)-4,4,5,5- tetramethyl-4,5-dihydro-1H-imidazoline-1-oxyl-3-oxide (2) was synthesized and its magneto-structural correlation is discussed. 2 crystallizes in the space group C2/c with hydrogen bonding between two independent molecules (A and B) having different dihedral angles between the azaindole rings and nitronyl nitroxide units in the asymmetric unit. The molecules are further linked together with axisymmetrically related molecules (A* and B*) through hydrogen bonds (A-B* and A*-B) and π stacking (A-A*). The temperature dependence of the magnetic susceptibility reveals that half of the radicals are antiferromagnetically coupled as a dimer (singlet-triplet energy gap: 2J = -64 cm-1) while the other half behaves as an isolated monomer. DFT calculations (UB3LYP/6-31G*) of the dimeric coordinates extracted from the X-ray analysis rationalize the fact that the π-stacked A-A* dimer contributes to the antiferromagnetic coupling by a close contact between nitronyl nitroxide units.
COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF
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Paragraph 0078-0079; 00151-00152, (2021/10/30)
The present invention relates to novel Collagen 1 translation inhibitors, composition and methods of preparation thereof, and uses thereof for treating Fibrosis including lung, liver, kidney, cardiac and dermal fibrosis, IPF, wound healing, scarring and Gingival fibromatosis, Systemic Sclerosis, and alcoholic and non-alcoholic steatohepatitis (NASH).
Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity
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, (2008/06/13)
Aminopiperidine derivatives of formula (I) and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.