172882-71-2Relevant academic research and scientific papers
Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV
Nakatani, Shingo,Hidaka, Koushi,Ami, Ei'Ichi,Nakahara, Koichiro,Sato, Akihiko,Nguyen, Jeffrey-Tri,Hamada, Yoshio,Hori, Yasuko,Ohnishi, Nobuyuki,Nagai, Akinori,Kimura, Tooru,Hayashi, Yoshio,Kiso, Yoshiaki
experimental part, p. 2992 - 3004 (2009/04/05)
Several non-natural D-amino acid derivatives were introduced as P2/P3 residues in allophenylnorstatine-containing (Apns; (2S,3S)-3-amino-2-hydroxy-4- phenylbutyric acid) HIV protease inhibitors. The synthetic analogues exhibited potent inhibitory activity
Potent human immunodeficiency virus type 1 protease inhibitors that utilize noncoded D-amino acids as P2/P3 ligands
Jungheim, Louis N.,Shepherd, Timothy A.,Baxter, Angela J.,Burgess, Jeffrey,Hatch, Steven D.,Lubbehusen, Penny,Wiskerchen, MaryAnn,Muesing, Mark A.
, p. 96 - 108 (2007/10/03)
Noncoded D-amino acids have been designed to replace the quinaldic amide- asparaginyl moiety (P2/P3 ligand) found in several potent human immunodeficiency virus (HIV) protease inhibitors such as LY289612. The substituted nitrogen, op
