172896-35-4

Upstream product

• 16516-12-4 Monothiomalonsaeure-O,O-diethylester 
• 100-61-8 N-methylaniline 

Downstream Products

• 147079-88-7 4-hydroxy-1-methyl-6-methylsulfanyl-2-thioxo-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 172896-85-4 N-methyl-N-phenylthiocarbamoylacetic acid 

Relevant academic research and scientific papers

Quinoline-3-carbothioamides and related compounds as novel immunomodulating agents

A series of quinoline-3-carbothioamides and their analogues was prepared via four synthetic routes and evaluated for their antinephritic and immunomodulating activities. The optimal compound 9g strongly inhibited the T-cell independent antibody production in mice immunized with TNP-LPS and was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice.

The first synthesis of N-alkyl-N-arylthiocarbamoylacetates and acetic acids

N-Alkyl-N-arylthiocarbamoylacetates, the key intermediates for the synthesis of novel antinephritic agents, have been prepared for the first time. Some of the esters were in turn hydrolyzed to the corresponding acids. An alternative, indirect synthetic route was also developed to prepare some unusual acids.