172902-00-0Relevant academic research and scientific papers
Discovery of L-755,507: A subnanomolar human β3 adrenergic receptor agonist
Parmee, Emma R.,Ok, Hyun O.,Candelore, Mari R.,Tota, Laurie,Deng, Liping,Strader, Catherine D.,Wyvratt, Matthew J.,Fisher, Michael H.,Weber, Ann E.
, p. 1107 - 1112 (2007/10/03)
A study of 4-acylaminobenzenesulfonamides in a cloned human β3 adrenergic receptor assay resulted in the discovery of n-hexylurea, L- 755,507 (22). This 0.43 nM β3 agonist, which is > 440-fold selective over both β1 and β2 binding, is among the most potent human β3 agonists reported to date.
