172914-59-9Relevant academic research and scientific papers
Synthesis of α-substituted β-amidophosphines by diastereoselective alkylation. A new access to chiral ligands for asymmetric catalysis
Leautey,Castelot-Deliencourt,Jubault,Pannecoucke,Quirion
, p. 5566 - 5571 (2001)
Chiral β-amidophosphine boranes 7a-f can be diastereoselectively alkylated, using O-protected amino-alcohols as chiral inducers, to furnish α-substituted β-amidophosphine boranes 8a-f and 9-12 with up to 72% diastereoisomeric excess. Selective deprotection afforded optically pure carboxylic derivative 13 which is a key intermediate for the synthesis of various potential chiral ligands for asymmetric catalysis.
