172915-18-3Relevant academic research and scientific papers
The transformations of 4-heteroarylaminomethylene-5(4H)-oxazolones into dehydropeptide derivatives
Aljaz-Rozic,Svete,Stanovnik
, p. 1605 - 1611 (1995)
2-Phenyl-4-heteroarylaminomethylene-5(4H)-oxazolones 3, which were prepared from the corresponding N,N-dimethyl-N'-heteroarylformamidines 1 and hippuric acid 2 in acetic anhydride, react with amino acids giving dehydropeptide derivatives 4, 5, and 6 as products. Dehydration of N-protected peptides 7-10, containing glycine at the C-terminal, followed by the reaction with formamidines 1 gave 2-substituted-4-heteroarylaminomethylene-5(4H)-oxazolones 11-14.
