172931-96-3Relevant articles and documents
BENZYLIDENE RHODANINES
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, (2008/06/13)
This invention provides novel benzylidene rhodanines which are useful as agents in treating or preventing conditions associated with . beta.-amyloid peptide. This invention further provides methods of treating or preventing Alzheimer's Disease which comprises administering to a mammal in need thereof an effective amount of one or more of the benzylidene rhodanines of the present invention.
Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D
Whitesitt, Celia A.,Simon, Richard L.,Reel, Jon K.,Sigmund, Sandra K.,Phillips, Michael L.,Shadle, J. Kevin,Heinz, Lawrence J.,Koppel, Gary A.,Hunden, David C.,Lifer, Sherryl L.,Berry, Dennis,Ray, Judy,Little, Sheila P.,Liu, Xiadong,Marshall, Winston S.,Panetta, Jill A.
, p. 2157 - 2162 (2007/10/03)
Non peptide inhibitors of cathepsin D, an aspartyl protease that has been implicated in many disease states including Alzheimer's disease, were prepared and evaluated. The most potent inhibitor of cathepsin D in this series was found to be (Z)-5-[[4-(4-be
