172932-06-8

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 88-75-5 2-hydroxynitrobenzene 
• 101-84-8 diphenylether 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1493-27-2 ortho-nitrofluorobenzene 
• 88-73-3 2-Chloronitrobenzene 
• 67-36-7 4-phenoxy benzaldehyde 

Downstream Products

• 1596272-14-8 methyl 2-(hydroxy(4-(2-nitrophenoxy)phenyl)methyl)acrylate 
• 1596272-65-9 (E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(4-(7-chloroquinolin-4-ylamino)butyl)guanidino)phenoxy)phenyl)-2-methylacrylate 
• 1596272-63-7 (E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(3-(7-chloroquinolin-4-ylamino)propyl)guanidino)phenoxy)phenyl)-2-methylacrylate 
• 1596272-61-5 (E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)guanidino)phenoxy)phenyl)-2-methylacrylate 
• 1596272-60-4 (E)-methyl 3-(4-(2-((E)-2-(3-chlorophenyl)-3-cyclopropylguanidino)phenoxy)phenyl)-2-methylacrylate 
• 1596272-59-1 (E)-methyl 3-(4-(2-((E)-3-benzyl-2-phenylguanidino)phenoxy)phenyl)-2-methylacrylate 
• 1596272-56-8 (E)-methyl 3-(4-(2-((E)-2-(3-chlorophenyl)-3-(4-(7-chloroquinolin-4-ylamino)butyl)guanidino)phenoxy)phenyl)-2-methylacrylate 
• 1596272-53-5 (E)-methyl 3-(4-(2-((E)-3-(3-(6-chloronaphthalen-1-ylamino)propyl)-2-(3-chlorophenyl)guanidino)phenoxy)phenyl)-2-methylacrylate 
• 1596272-52-4 (E)-methyl3-{4-[2-((E)-3-(2-(6-chloronaphthalen-1-ylamino)ethyl)-2-(3-chlorophenyl)guanidino)phenoxy]phenyl}-2-methylacrylate 
• 1596272-51-3 (E)-methyl 3-(4-(2-((E)-3-cyclopropyl-2-phenylguanidino)phenoxy)phenyl)-2-methylacrylate 
• 1596272-50-2 (E)-methyl 3-(4-(2-((E)-3-benzyl-2-phenylguanidino)phenoxy)phenyl)-2-methylacrylate 
• 1596272-48-8 (E)-methyl 3-(4-(2-((E)-3-(4-(7-chloroquinolin-4-ylamino)butyl)-2-phenylguanidino)phenoxy)phenyl)-2-methylacrylate 
• 1596272-45-5 (E)-methyl 3-(4-(2-((E)-3-(3-(7-chloroquinolin-4-ylamino)propyl)-2-phenylguanidino)phenoxy)phenyl)-2-methylacrylate 
• 1596272-43-3 (E)-methyl 3-(4-(2-((E)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)-2-phenylguanidino)phenoxy)phenyl)-2-methylacrylate 

Relevant academic research and scientific papers

Importance of the proximity and orientation of ligand-linkage to the design of cinnamate-GW9662 hybrid compounds as covalent PPAR agonists

Covalent agonists of PPAR cause unique receptor conformational changes and behave as selective PPAR modulators, whereas there are few covalent agonists other than endogenous unsaturated fatty acids metabolites. Previously, we established a cell-based stra

Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents

Synthesis and bioevaluation of new diaryl ether hybridized quinoline derivatives as antiplasmodial, antibacterial and antifungal agents is reported. It was encouraging to discover that several compounds displayed 2-3 folds better efficacy than chloroquine in chloroquine-resistant K1 strain of Plasmodium falciparum. Further, a few members of the library displayed good antibacterial efficacy against gram positive strains of bacteria but none of the compounds displayed any significant antifungal activity.

Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid

A novel series of nonnucleoside HCV NS5B polymerase inhibitors were prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a high throughput screening lead. SAR studies combined with structure based drug design focusing on the southern heterobiaryl region of the template led to the synthesis of several potent and orally bioavailable lead compounds. X-ray crystallography studies were also performed to understand the interaction of these inhibitors with HCV NS5B polymerase.