172936-67-3Relevant articles and documents
A novel pyridazinone derivative as a nonprostanoid PGI2 agonist
Tsubaki, Kazunori,Taniguchi, Kiyoshi,Tabuchi, Seiichiro,Okitsu, Osamu,Hattori, Kouji,Seki, Jiro,Sakane, Kazuo,Tanaka, Hirokazu
, p. 2787 - 2790 (2007/10/03)
A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 μM and has high oral bioavailability (