172937-47-2Relevant academic research and scientific papers
A novel pyridazinone derivative as a nonprostanoid PGI2 agonist
Tsubaki, Kazunori,Taniguchi, Kiyoshi,Tabuchi, Seiichiro,Okitsu, Osamu,Hattori, Kouji,Seki, Jiro,Sakane, Kazuo,Tanaka, Hirokazu
, p. 2787 - 2790 (2000)
A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 μM and has high oral bioavailability (
Naphthalene derivatives as prostaglandin I2 agonsists
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, (2008/06/13)
A compound of the formula STR1 wherein R1 is carboxy or protected carboxy, R2 is hydrogen, hydroxy or protected hydroxy, R3 is hydrogen, hydroxy, protected hydroxy, etc., R4 is hydrogen or halogen, A1
