172967-06-5

Basic information

• Product Name: (R)-3-(3-Fluoro-4-piperidin-1-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one
• CAS NO: 172967-06-5
• Molecular Weight: 294.326
• Mol File: 172967-06-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-3-(3-Fluoro-4-piperidin-1-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(3-Fluoro-4-piperidin-1-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one(172967-06-5)
• EPA Substance Registry System: (R)-3-(3-Fluoro-4-piperidin-1-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one(172967-06-5)

Safety Data

• Hazardous Substances Data: 172967-06-5(Hazardous Substances Data)

Upstream product

• 172967-05-4 C₁₉H₂₁FN₂O₂ 
• 60456-26-0 (R)-glycidyl butyrate 
• 172967-04-3 1-(2-fluoro-4-nitrophenyl)piperidine 
• 369-34-6 3,4-difluoronitrobenzene 
• 85983-56-8 3-fluoro-4-(piperidin-1-yl)aniline 

Downstream Products

• 221202-55-7 1-Benzoyl-3-[(S)-3-(3-fluoro-4-piperidin-1-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-thiourea 
• 172967-08-7 (R)-5-Azidomethyl-3-(3-fluoro-4-piperidin-1-yl-phenyl)-oxazolidin-2-one 
• 221201-28-1 (S)-N-[3-(3-fluoro-4-piperidylphenyl)-2-oxo-5-oxazolidinyl]methylamine 
• 556801-60-6 Methanesulfonic acid (R)-3-(3-fluoro-4-piperidin-1-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester 

Relevant articles and documents

A method for the prevention or treatment of mycobacterial diseases

Disclosed in the present invention is a drug for preventing or treating mycobacterial diseases. In particular, disclosed is the use of a compound represented by the following general formula (I) or pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs thereof in preparing drugs for preventing or treating mycobacterial diseases, providing a new way for the prevention and treatment of tuberculosis and the like.

Structure-activity relationship (SAR) studies on oxazolidinone antibacterial agents. 2.1) Relationship between lipophilicity and antibacterial activity in 5-thiocarbonyl oxazolidinones

5-Thiourea and 5-dithiocarbamate oxazolidinones were synthesized as a continuation of research on 5-thiocarbonyl oxazolidinone antibacterial agents considering the hydrophobic parameters of the molecule. The structure-activity relationship (SAR) study revealed that the antibacterial activity on 5-thiocarbonyl oxazolidinones was significantly affected by the lipophilicity, especially the calculated log P value and the balance between 5-hydrophilic (or hydrophobic) substituent and hydrophobic (or hydrophilic) substituents on the benzene ring. Some of 5-thiocarbonyl oxazolidinones were found to have good in vitro antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).