172992-24-4

Upstream product

• 501-53-1 benzyl chloroformate 
• 132502-59-1 tert-butyl [3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]carbamate 
• 71-44-3 Spermine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 172992-25-5 N¹,N⁴,N⁹-tri-benzyloxycarbonyl-spermine 
• 172992-26-6 (3-Benzyloxycarbonylamino-propyl)-(4-{benzyloxycarbonyl-[3-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylamino)-propyl]-amino}-butyl)-carbamic acid benzyl ester 
• 172992-39-1 (3-Benzyloxycarbonylamino-propyl)-[4-(benzyloxycarbonyl-{3-[(S)-3-(4-benzyloxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-amino)-butyl]-carbamic acid benzyl ester 
• 172992-28-8 (3-Benzyloxycarbonylamino-propyl)-[4-(benzyloxycarbonyl-{3-[(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentyl)-(4,4,4-trifluoro-butyryl)-amino]-propyl}-amino)-butyl]-carbamic acid benzyl ester 
• 115976-93-7 philanthotoxin-343 

Relevant academic research and scientific papers

Inhibition of growth of B16 murine melanoma cells by novel spermine analogues

To develop new cytotoxins, which could find use as anti-cancer agents, polyamine conjugates were synthesized containing spermine and an anthracene or acridine unit. Spermine is known to groove-bind to DNA; anthracene and acridine are known to intercalate. It was hoped that these polyamine-polyaromatic conjugates would use both modes of binding. Studies of growth inhibition of B16 murine melanoma cells showed the conjuates to be more effective than either spermine, anthracene-9-carboxylic acid or acridine-9-carboxylic acid, and of the conjugates, the acridine derivative showed greatest activity.

Total Synthesis of Polyamine Amides PhTX-4.3.3 and PhTX-3.4.3: Reductive Alkylation is a Rapid, Practical Route to Philanthotoxins

Reductive alkylation allows a rapid and practical entry to the polyamine amide wasp toxin philanthotoxin-4.3.3.Philanthotoxin-3.4.3 has been prepared, in two steps, by the monoacylation of sperimine.These polyamine amides are selective molecular pharmacological tools for cation channels gated by glutamic acid and acetylcholine, and may have potential as a neuroprotective agents.