172992-35-7

Usage

Structure

Complex structure comprising a 3-(4-benzyloxy-phenyl) group attached to a 2-butyrylamino-propionic acid moiety

Functional Groups

3-(4-benzyloxy-phenyl) group
2-butyrylamino group

Derivatives

Derivative of benzyl group
Derivative of butyrylamino group

Applications

Pharmaceutical development
Drug discovery
Biochemical research

Utility

Valuable building block for creating new molecules

Significance

Used in organic synthesis
Employed in medicinal chemistry

Upstream product

• 172992-34-6 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid methyl ester 
• 34805-17-9 methyl 2S-amino-3-(4-benzyloxyphenyl)propionate hydrochloride 

Downstream Products

• 172992-36-8 N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-hydroxy-butylcarbamoyl)-ethyl]-butyramide 
• 172992-39-1 (3-Benzyloxycarbonylamino-propyl)-[4-(benzyloxycarbonyl-{3-[(S)-3-(4-benzyloxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-amino)-butyl]-carbamic acid benzyl ester 
• 125376-03-6 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester 
• 172992-37-9 N-[(S)-2-(4-Benzyloxy-phenyl)-1-(4-oxo-butylcarbamoyl)-ethyl]-butyramide 
• 115976-91-5 Philanthotoxin 433 
• 115976-93-7 philanthotoxin-343 
• 937377-32-7 (4-{7-[3-(4-benzyloxy-phenyl)-2-butyrylamino-propionylamino]-heptylamino}-butyl)-carbamic acid tert-butyl ester 
• 937377-31-6 N-[2-(4-benzyloxy-phenyl)-1-(7-hydroxy-heptylcarbamoyl)-ethyl]-butyramide 

Relevant academic research and scientific papers

A subtype-selective, use-dependent inhibitor of native AMPA receptors

AMPA (α-amino-3-hydroxy-5-methyl-4-isooxazole) receptors (AMPARs) are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. Two sub

Practical synthesis of unsymmetrical polyamine amides

Desymmetrisation of readily available symmetrical polyamines is an important first step in the synthesis of many polyamine containing natural products. Likewise in the synthesis of polyamine amides which are potentially useful for gene delivery and as neuroprotectants, based upon channel blocking toxins found in certain wasp and spider venoms. The application of trifluoroacetyl as a protecting group allows unsymmetrical polyamine amides to be easily prepared on a gram scale.

Total Synthesis of Polyamine Amides PhTX-4.3.3 and PhTX-3.4.3: Reductive Alkylation is a Rapid, Practical Route to Philanthotoxins

Reductive alkylation allows a rapid and practical entry to the polyamine amide wasp toxin philanthotoxin-4.3.3.Philanthotoxin-3.4.3 has been prepared, in two steps, by the monoacylation of sperimine.These polyamine amides are selective molecular pharmacological tools for cation channels gated by glutamic acid and acetylcholine, and may have potential as a neuroprotective agents.