173034-70-3

Basic information

• Product Name: [1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDIN-2(R)-YL]-METHANOL
• Synonyms: [1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDIN-2(R)-YL]-METHANOL;(R)-1-[(R)-α-Methylbenzyl)-2-aziridinemethanol;[1-(1μ(R)-α-methylbenzyl)-aziridin-2(R)-yl]-methanol, (R)-1-[(R)-1-α-Methylbenzyl)-2-aziridinemethanol;(R)-1-[(R)-α-Methylbenzyl)aziridine-2-Methanol; (R)-1-((R)-ALPHA-METHYLBENZYL)AZIRIDINE-2-METHANOL
• CAS NO: 173034-70-3
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 173034-70-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 51-56 °C(lit.)
• Boiling Point: 240.6°C at 760 mmHg
• Flash Point: 220 °F
• Appearance: /
• Density: 1.118g/cm³
• Vapor Pressure: 0.0203mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: [1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDIN-2(R)-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDIN-2(R)-YL]-METHANOL(173034-70-3)
• EPA Substance Registry System: [1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDIN-2(R)-YL]-METHANOL(173034-70-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 173034-70-3(Hazardous Substances Data)

Usage

General Description

[1-(1'(R)-alpha-methylbenzyl)-aziridin-2(R)-yl]-methanol is a chemical compound with a complex molecular structure. It contains an aziridine ring, which is a three-membered heterocycle with one nitrogen atom. The presence of the alpha-methylbenzyl group and the aziridin-2(R)-yl group indicates that it has potential biological activity and may be used in pharmaceutical applications. The methanol group attached to the aziridine ring suggests that it may have solubility in polar solvents. Overall, this chemical compound has potential implications for a variety of applications in the fields of medicine, chemistry, and materials science.

InChI:InChI=1/C11H15NO/c1-9(12-7-11(12)8-13)10-5-3-2-4-6-10/h2-6,9,11,13H,7-8H2,1H3/t9-,11-,12?/m1/s1

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 68820-82-6 (2R)-1[(R)-α-methylbenzyl]-2-aziridinecarboxylate ethyl ester 

Downstream Products

• 1534390-96-9 (2S,3S,4S)-3,4,5-tris(benzyloxy)-2-(((R)-1-phenylethyl)amino)pentanoic acid 
• 1534390-93-6 (2R,3S,4S)-3,4,5-tris(benzyloxy)-2-(((R)-1-phenylethyl)amino)pentan-1-ol 
• 1534390-95-8 (R)-1-((R)-1-phenylethyl)-2-((1S,2S)-1,2,3-tris(benzyloxy)propyl)aziridine 
• 1534390-94-7 (2R,3S)-ethyl 2,3-dihydroxy-3-((R)-1-((R)-1-phenylethyl)aziridin-2-yl)propanoate 
• 1316816-53-1 ethyl 2,3-dihydroxy-3-{(R)-1-[(R)-1-phenylethyl]aziridin-2-yl}propanoate 
• 1458024-18-4 (2R,3S,4S)-2-(hydroxymethyl)-1-((R)-1-phenylethyl)pyrrolidine-3,4-diol 
• 1458024-17-3 ((2R,3S,4R)-3,4-dihydroxy-5-oxo-1-((R)-1-phenylethyl)pyrrolidin-2-yl)methyl acetate 
• 1316816-58-6 (2R,3R,4R)-2-(hydroxymethyl)-1-((R)-1phenylethyl)pyrrolidine-3,4-diol 
• 1316816-55-3 ((2R,3R,4S)-3,4-dihydroxy-5-oxo-1-((R)-1-phenylethyl)pyrrolidin-2-yl)methyl acetate 
• 1458024-16-2 ((R)-3,4-dihydroxy-5-oxo-1-((R)-1-phenylethyl)pyrrolidin-2-yl)methyl acetate 
• 1082763-51-6 (E)-ethyl 3-((S)-1-((R)-1-phenylethyl)aziridin-2-yl)acrylate 
• 1337903-86-2 (1R,2S)-2-(bromomethyl)-1-(α-methylbenzyl)aziridine 
• 1337903-84-0 (1R,2R)-2-(bromomethyl)-1-(α-methylbenzyl)aziridine 
• 1082763-29-8 (1R,2R)-2-methoxymethyl-1-(α-methylbenzyl)aziridine 

Relevant articles and documents

SPHINGOLIPID DERIVATIVES AND THE COMPOSITION FOR ANTI-CANCER CONTAINING THE SAME

Disclosed are a novel sphingolipid derivative having a sphingosine kinase suppressing activity and a composition containing the same. When the newly synthesized sphingolipid derivative of the invention is used, it is possible to maintain concentrations of ceramide and sphingosine to be high by preventing ceramide and sphingosine from being phosphorylated due to sphingosine kinase since an activity of sphingosine kinase is suppressed. In addition, since the apoptosis is induced in a cancer cell by ceramide and sphingosine, it is possible to treat or prevent a cancer or disease related to the cancer. Further, it is possible to treat or prevent a hyper- proliferative disease such as cancer or proliferation-promoting activity of sphingosine kinase. Accordingly, the composition containing the same can be used as a composition for suppressing sphingosine kinase and a composition for treating or preventing a cancer or hyper-proliferative disease.