173092-07-4Relevant academic research and scientific papers
Pyrrolinone-based HIV protease inhibitors. Design, synthesis, and antiviral activity: Evidence for improved transport
Smith III, Amos B.,Hirschmann, Ralph,Pasternak, Alexander,Guzman, Mark C.,Yokoyama, Akihisa,Sprengeler, Paul A.,Darke, Paul L.,Emini, Emilio A.,Schleif, William A.
, p. 11113 - 11123 (2007/10/03)
Pyrrolinone-based peptidomimetics, the first mimics of β-strands, are potent inhibitors of HIV-1 protease. Importantly, the bis(pyrrolinones) described herein proved to be more active in cellular antiviral assays compared with an analogous peptide-derived
