173101-54-7 Usage
Description
Iso CephaloMannine, an isomer of Cephalomannine (C258500), is a white solid substance that serves as an impurity in the active pharmaceutical ingredient, Paclitaxel (P132500). It is known as Paclitaxel impurity A and exhibits unique binding properties to the N-terminal 31 amino acids of the beta-tubulin subunit in the microtubule, distinguishing it from tubulin dimers.
Uses
Used in Pharmaceutical Industry:
Iso CephaloMannine is used as an impurity in the production of Paclitaxel, a widely used chemotherapy drug. Its presence in the active pharmaceutical ingredient is significant due to its unique binding properties, which may affect the overall efficacy and safety of the drug.
Iso CephaloMannine is used as a research compound for studying the effects of Paclitaxel impurities on the drug's pharmacological properties and potential side effects. This helps in understanding the role of impurities in the overall performance of the drug and contributes to the development of improved formulations and drug delivery systems.
Used in Quality Control and Regulatory Compliance:
Iso CephaloMannine is used as a reference material in the quality control and regulatory compliance processes for Paclitaxel. It helps in the identification, quantification, and control of impurities in the drug, ensuring that the final product meets the required safety and efficacy standards.
Used in Drug Development and Research:
Iso CephaloMannine is used as a starting material or intermediate in the synthesis of new drugs or drug candidates with potential applications in various therapeutic areas. Its unique chemical properties and binding characteristics make it a valuable compound for exploring novel therapeutic approaches and developing innovative drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 173101-54-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,1,0 and 1 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 173101-54:
(8*1)+(7*7)+(6*3)+(5*1)+(4*0)+(3*1)+(2*5)+(1*4)=97
97 % 10 = 7
So 173101-54-7 is a valid CAS Registry Number.
173101-54-7Relevant articles and documents
Paclitaxel analogues from Taxus x media cv. Hicksii
Gabetta, Bruno,Fuzzati, Nicola,Orsini, Paolo,Peterlongo, Federico,Appendino, Giovanni,Vander Velde, David G.
, p. 219 - 223 (1999)
The roots of T. x media Rehd. cv. Hicksii gave three novel analogues of paclitaxel modified at the N-acyl residue (N-debenzoyl-N-α-methylbutyryl paclitaxel and N-debenzoyl-N-cinnamoyl paclitaxel, 1b and 1c, respectively) or at the ester group at C-2 (2-debenzoyl-2-tigloyl paclitaxel, 1d). Compounds 1b and 1d showed reduced cytotoxicity and tubulin binding compared to paclitaxel, while 1c retained substantial activity in these assays.
