173142-28-4

Upstream product

• 231619-09-3 (2R,3S,4S,5R,6R)-6-azido-2,3-epoxy-4,5,7-tris(benzyloxy)-2(E)-hepten-1-ol 

Downstream Products

• 231619-03-7 N,N-bis<<(2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>pyrrolidinyl>methyl>amine 
• 231618-97-6 (2R,3R,4R,5R)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-[(S)-1-hydroxy-2-(toluene-4-sulfonyloxy)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 231619-01-5 (1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-2-<2-acetamido-1-(benzyloxy)ethyl>-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>pyrrolidine 
• 231619-00-4 (1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-2-<2-amino-1-(benzyloxy)ethyl>-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>pyrrolidine 
• 231618-99-8 (1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-2-<2-azido-1-(benzyloxy)ethyl>-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>pyrrolidine 
• 231619-02-6 (1'R,2R,3R,4R,5R)-2-<2-acetamido-1-(benzyloxy)ethyl>-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>pyrrolidine 
• 231618-93-2 (2R,3R,4R,5R)-N-butyloxycarbonyl-2-(acetamidomethyl)-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>pyrrolidine 
• 231618-98-7 (1'R,2R,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>-2-<2-azido-1-hydroxyethyl>pyrrolidine 
• 231618-90-9 (2R,3R,4R,5R)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 231618-96-5 (2R,3R,4R,5R)-N-butyl-2-(acetamidomethyl)-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>pyrrolidine 
• 231618-88-5 (2R,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>-2-(hydroxymethyl)pyrrolidine 
• 231618-91-0 (2R,3R,4R,5R)-N-butyloxycarbonyl-2-(azidomethyl)-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>pyrrolidine 
• 231618-92-1 (2R,3R,4R,5R)-N-butyloxycarbonyl-2-(aminomethyl)-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>pyrrolidine 
• 231618-87-4 (2S,3R,4R,5R)-N-butyloxycarbonyl-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>pyrrolidine-2-carbaldehyde 

Relevant academic research and scientific papers

A versatile synthetic strategy for the preparation and discovery of new iminocyclitols as inhibitors of glycosidases

A series of iminocyclitols was prepared using a versatile synthetic strategy, and their inhibition of glycosidases was evaluated using capillary electrophoresis. The study has demonstrated that remarkable specificities in enzyme inhibition can be achieved with small modifications on the aglycon side chain and the ring nitrogen. Among the compounds synthesized, (2R,3R,4R,5R)-N-methyl-2(acetamidomethyl)-3,4-dihydroxy-5- (hydroxymethyl)pyrrolidine was found to be very potent against β-N- acetylhexosaminidase P with the K(i) value of 80 nM.

Iminocyclitol inhibitors of hexoaminidase and glycosidase

Designed iminocylitols that have potent inhibition activity with respect to hexominidases and glycosides are disclosed.