173143-73-2

Basic information

• Product Name: [1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDINE-2(S)-YL]-METHANOL
• Synonyms: [1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDINE-2(S)-YL]-METHANOL;(S)-1-[(R)-α-Methylbenzyl)-2-aziridinemethanol, [1-(1μ(R)-α-methylbenzyl)-aziridine-2(S)-yl]-methanol;(S)-1-[(R)-α-Methylbenzyl]-2-aziridinemethanol;(S)-1-[(R)-α-Methylbenzyl]aziridine-2-Methanol;(S)-1-[(R)-alpha-Methylbenzyl]aziridine-2-methanol 98%;(S)-1-[(R)-ALPHA-METHYLBENZYL]AZIRIDINE-2-METHANOL
• CAS NO: 173143-73-2
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 173143-73-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 30-35 °C(lit.)
• Boiling Point: 240.6°C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.118g/cm³
• Vapor Pressure: 0.0203mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: [1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDINE-2(S)-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDINE-2(S)-YL]-METHANOL(173143-73-2)
• EPA Substance Registry System: [1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDINE-2(S)-YL]-METHANOL(173143-73-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 173143-73-2(Hazardous Substances Data)

Usage

General Description

[1-(1'(R)-alpha-methylbenzyl)-aziridine-2(S)-yl]-methanol is a chemical compound with a complex structure that contains an aziridine ring, a benzyl group, and a methanol group. The aziridine ring is a three-membered heterocyclic ring containing nitrogen, and the addition of the benzyl group and methanol creates a compound with potential pharmaceutical and industrial applications. The alpha-methylbenzyl group is a chiral center, indicating that the compound has stereochemical properties that may impact its behavior and reactivity. Overall, [1-(1'(R)-alpha-methylbenzyl)-aziridine-2(S)-yl]-methanol is a unique and potentially versatile chemical with a variety of potential uses in various fields.

InChI:InChI=1/C11H15NO/c1-9(12-7-11(12)8-13)10-5-3-2-4-6-10/h2-6,9,11,13H,7-8H2,1H3/t9-,11+,12?/m1/s1

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 609826-46-2 (2S,αR)-3-hydroxy-2-[(α-methylbenzyl)amino]propyl 4-nitrobenzoate 
• 252351-20-5 (R)-2-[(α-methylbenzyl)amino]-1,3-propanediol 
• 68820-70-2 methyl (2S,1'R)-1-(1'-phenylethyl)-aziridine-2-carboxylate 
• 397849-98-8 N-[(R)-(+)-α-methylbenzyl]aziridine-2-(S)-carboxylic acid menthyl ester 
• 609826-54-2 (2S,αR)-(1-α-methylbenzyl-2-aziridinyl)methyl 4-nitrobenzoate 
• 68820-72-4 (2S)-1-[(R)-α-methylbenzyl]-2-aziridinecarboxylate ethyl ester 

Downstream Products

• 180196-03-6 (2S)-1-[(1R)-1-phenylethyl]aziridine-2-carbaldehyde 
• 678965-59-8 (S)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl 4-methylbenzenesulfonate 
• 887947-02-6 2(S)-((3-chlorophenoxy)methyl)-1-(1(R)-phenylethyl)aziridine 
• 945676-56-2 diethyl (R)-hydroxy {(S)-1-[(R)-1-phenylethyl]aziridin-2-yl}methylphosphonate 
• 945676-57-3 diethyl (S)-hydroxy {(S)-1-[(R)-1-phenylethyl]aziridin-2-yl}methylphosphonate 
• 945676-60-8 diethyl (R)-acetoxy {(S)-1-[(R)-1-phenylethyl]aziridin-2-yl}methylphosphonate 
• 945676-61-9 diethyl (S)-acetoxy {(S)-1-[(R)-1-phenylethyl]aziridin-2-yl}methylphosphonate 
• 925222-34-0 (R)-1-{((R)-1-phenylethyl)-2-[(Z)-styryl]}aziridine 
• 925222-35-1 (R)-1-{(R)-1-phenylethyl-2-[(E)-styryl]}aziridine 
• 925222-36-2 (R)-1-{((R)-1-phenylethyl)-2-[(Z)-3-phenylprop-1-enyl]}aziridine 
• 925222-37-3 (R)-1-{((R)-1-phenylethyl)-2-[(E)-3-phenylprop-1-enyl]}aziridine 
• 925222-29-3 (R)-2-{[(Z)-hexadec-1-enyl]-1-[(R)-1-phenylethyl]}aziridine 
• 925222-30-6 (1S,2R)-1-{[(R)-1-phenylethyl]aziridine-2-yl}hexadecane-1,2-diol 

Relevant articles and documents

Synthesis of the four enantiomers of diethyl 1,2-di(N-Boc-amino)propylphosphonates

A simple and efficient synthetic strategy to all four enantiomerically pure diethyl 1,2-di(N-Boc-amino)propylphosphonates has been elaborated starting from the corresponding N-[(R)-(1-phenylethyl)]aziridine-(2S)- and N-[(S)-(1-phenylethyl)]aziridine-(2R)-

Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases

Sphingosine 1-phosphate (S1P), a product of sphingosine kinases (SphK), mediates diverse biological processes such as cell differentiation, proliferation, motility, and apoptosis. In an effort to search and identify specific inhibitors of human SphK, the inhibitory effects of synthetic sphingoid analogs on kinase activity were examined. Among the analogs tested, we found two, SG12 and SG14, that have specific inhibitory effects on hSphK2. N,N-Dimethylsphingosine (DMS), a well-known SphK inhibitor, displayed inhibitory effects for both SphK1 and SphK2, as well as protein kinase C. In contrast, SG12 and SG14 exhibited selective inhibitory effects on hSphK2. Furthermore, SG14 did not affect PKC. In isolated platelets, SG14 blocked the conversion of sphingosine into sphingosine 1-phosphate significantly. This is the first report on the identification of a hSphK2-specific inhibitor, which may provide a useful tool for studying the biological functions of hSphK2.

Regiospecific reductive ring cleavage of N-substituted aziridine-2-carboxylates and An aziridine-2-methanol via catalytic hydrogenation using Pd as a catalyst

Regiospecific reductive ring cleavage was accomplished in the reaction of N-α-methylbenzyl substituted aziridine-2-carboxylate and aziridine-2-methanol under a catalytic hydrogenation condition. The regiospecificity was determined by the substituent at C-