173143-73-2

Usage

Uses

Used in Pharmaceutical Industry:
[1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDINE-2(S)-YL]-METHANOL is used as a pharmaceutical intermediate for its potential to be incorporated into the synthesis of various medicinal compounds. Its unique structure, including the aziridine ring and chiral center, may contribute to the development of new drugs with specific therapeutic targets.
Used in Chemical Synthesis:
In the field of organic chemistry, [1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDINE-2(S)-YL]-METHANOL serves as a key building block for the synthesis of complex organic molecules. Its reactive aziridine ring and the presence of a benzyl group make it a valuable precursor in the creation of novel chemical entities with potential applications in material science, agrochemicals, and other specialized industries.
Used in Research and Development:
[1-(1'(R)-ALPHA-METHYLBENZYL)-AZIRIDINE-2(S)-YL]-METHANOL is utilized as a research compound in academic and industrial laboratories. Its unique structural features allow scientists to explore its reactivity, stability, and potential interactions with biological systems, which can lead to advancements in understanding chemical behavior and the discovery of new applications.

InChI:InChI=1/C11H15NO/c1-9(12-7-11(12)8-13)10-5-3-2-4-6-10/h2-6,9,11,13H,7-8H2,1H3/t9-,11+,12?/m1/s1

Upstream product

• 68820-72-4 (2S)-1-[(R)-α-methylbenzyl]-2-aziridinecarboxylate ethyl ester 
• 609826-54-2 (2S,αR)-(1-α-methylbenzyl-2-aziridinyl)methyl 4-nitrobenzoate 
• 397849-98-8 N-[(R)-(+)-α-methylbenzyl]aziridine-2-(S)-carboxylic acid menthyl ester 
• 68820-70-2 methyl (2S,1'R)-1-(1'-phenylethyl)-aziridine-2-carboxylate 
• 252351-20-5 (R)-2-[(α-methylbenzyl)amino]-1,3-propanediol 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 609826-46-2 (2S,αR)-3-hydroxy-2-[(α-methylbenzyl)amino]propyl 4-nitrobenzoate 

Downstream Products

• 173143-74-3 2(S)-[1(R)-phenylethylamino]propan-1-ol 
• 444814-32-8 4(R)-(chloromethyl)-3-(1'(R)-α-methylbenzyl)oxazolidin-2-one 
• 678965-59-8 (S)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl 4-methylbenzenesulfonate 
• 867153-75-1 (S)-4-iodomethyl-3-[(R)-1-phenylethyl]oxazolidine-2-one 
• 925222-34-0 (R)-1-{((R)-1-phenylethyl)-2-[(Z)-styryl]}aziridine 
• 925222-35-1 (R)-1-{(R)-1-phenylethyl-2-[(E)-styryl]}aziridine 
• 925222-36-2 (R)-1-{((R)-1-phenylethyl)-2-[(Z)-3-phenylprop-1-enyl]}aziridine 
• 925222-37-3 (R)-1-{((R)-1-phenylethyl)-2-[(E)-3-phenylprop-1-enyl]}aziridine 
• 925222-29-3 (R)-2-{[(Z)-hexadec-1-enyl]-1-[(R)-1-phenylethyl]}aziridine 
• 925222-30-6 (1S,2R)-1-{[(R)-1-phenylethyl]aziridine-2-yl}hexadecane-1,2-diol 
• 925222-46-4 (2S,3S,4R)-2-[(R)-1-phenylethylamino]octadecane-1,3,4-triol 
• 1093278-32-0 (S)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl methanesulfonate 
• 1458024-20-8 ((S)-3,4-dihydroxy-5-oxo-1-((R)-1-phenylethyl)pyrrolidin-2-yl)methyl acetate 
• 1316816-62-2 ((2S,3S,4R)-3,4-dihydroxy-5-oxo-1-((R)-1-phenylethyl)pyrrolidin-2-yl)methyl acetate 

Relevant academic research and scientific papers

Synthesis of the four enantiomers of diethyl 1,2-di(N-Boc-amino)propylphosphonates

A simple and efficient synthetic strategy to all four enantiomerically pure diethyl 1,2-di(N-Boc-amino)propylphosphonates has been elaborated starting from the corresponding N-[(R)-(1-phenylethyl)]aziridine-(2S)- and N-[(S)-(1-phenylethyl)]aziridine-(2R)-

Synthesis of four enantiomers of 2-acetamido-1-hydroxypropylphosphonates

Enantiomerically pure diethyl 2-acetamido-1-hydroxypropylphosphonates were synthesised from N-[(R)-(1-phenylethyl)]aziridine-(2S)- and N-[(S)-(1-phenylethyl)]aziridine-(2R)-carboxaldehydes via phosphonylation followed by acetylation of the hydroxy groups

Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases

Sphingosine 1-phosphate (S1P), a product of sphingosine kinases (SphK), mediates diverse biological processes such as cell differentiation, proliferation, motility, and apoptosis. In an effort to search and identify specific inhibitors of human SphK, the inhibitory effects of synthetic sphingoid analogs on kinase activity were examined. Among the analogs tested, we found two, SG12 and SG14, that have specific inhibitory effects on hSphK2. N,N-Dimethylsphingosine (DMS), a well-known SphK inhibitor, displayed inhibitory effects for both SphK1 and SphK2, as well as protein kinase C. In contrast, SG12 and SG14 exhibited selective inhibitory effects on hSphK2. Furthermore, SG14 did not affect PKC. In isolated platelets, SG14 blocked the conversion of sphingosine into sphingosine 1-phosphate significantly. This is the first report on the identification of a hSphK2-specific inhibitor, which may provide a useful tool for studying the biological functions of hSphK2.

One-pot acylation and fractional crystallization: Preparation of optically active serinol monobenzoates

Mono-O-acylation of (R)-2-(α-methylbenzyl)amino-1,3-propanediol 1 with 4-nitrobenzoyl chloride and DMAP in dichloromethane at room temperature gave crystals of optically active (2S,αR)-3-hydroxy-2-(α-methylbenzyl)aminopropyl 4-nitrobenzoate hydrochloride

Regiospecific reductive ring cleavage of N-substituted aziridine-2-carboxylates and An aziridine-2-methanol via catalytic hydrogenation using Pd as a catalyst

Regiospecific reductive ring cleavage was accomplished in the reaction of N-α-methylbenzyl substituted aziridine-2-carboxylate and aziridine-2-methanol under a catalytic hydrogenation condition. The regiospecificity was determined by the substituent at C-