173168-55-3Relevant academic research and scientific papers
Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B)
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, (2008/06/13)
The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.
Asymmetric Synthesis of Chiral, Nonracemic Dialkyl α-Hydroxyarylmethyl- and α-, β- and γ-Hydroxyalkylphosphonates from Keto Phosphonates
Meier, Chris,Laux, Wolfgang H. G.,Bats, Jan W.
, p. 1963 - 1980 (2007/10/03)
The enantioselective synthesis of α-hydroxyarylmethylphosphonates 2a-p by the oxazaborolidine-catalyzed reduction of α-keto phosphonates 1a-p using different boranes 4a-c was studied in detail.Moderate to good enantioselectivities are found (up to 80perce
