17318-70-6Relevant articles and documents
Practical routes to the triarylsulfonyl chloride intermediate of a β3 adrenergic receptor agonist
Ikemoto, Norihiro,Liu, Jinchu,Brands, Karel M.J.,McNamara, James M.,Reider, Paul J.
, p. 1317 - 1325 (2007/10/03)
A β3 adrenergic receptor agonist was prepared on a multi-kilogram scale in high yield and purity via a convergent synthesis. A key intermediate in this synthesis was an arylthiazolylbenzenesulfonyl chloride. The triaryl segment of this sulfonyl chloride was assembled at the thiazole ring via coupling of α-haloketone and thiobenzamide precursors (Hantzsch synthesis). Three strategies for introducing the para-sulfonyl chloride moiety were developed and evaluated. The sulfonation/chlorination and diazotization/chlorosulfonylation routes were found the most efficient.
Sulphonamides derived from diarylmethanes, the processes for preparing them and pharmaceutical compositions containing them
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, (2008/06/13)
The invention relates to new compounds corresponding to formula I: STR1 in which: W represents C=O, CH2 or CHOH, Z represents STR2 R1 and R2 represent especially Cl or F, R, R' and R" represent especially H, X represents especially CH2, Y represents especially COOH, u and v are two integers ranging from 0 to 10, p and q take the value 0 or 1, n and m are two integers ranging 0 to 10 and t is 0 or 1 the total number of carbon atoms in the chain STR3 ranging from 2 to 20, and to their physiologically acceptable salts obtained with organic or inorganic acids. These compounds are useful for preparing medicinal products which have, especially, anti-inflammatory properties.
