173190-69-7Relevant academic research and scientific papers
Discovery of new chalone adamantyl arotinoids having RXRα-modulating and anticancer activities
Ao, Mingtao,Hu, Xianwen,Qian, Yuqing,Li, Boqun,Zhang, Jianyu,Cao, Yin,Zhang, Yuxiang,Guo, Kaiqiang,Qiu, Yingkun,Jiang, Fuquan,Wu, Zhen,Fang, Meijuan
, (2021/06/07)
In the present study, a new series of chalcone adamantly arotinoids (chalcone AdArs) derived from RAR antagonist MX781, are synthesized, characterized, and evaluated for the biological activities in vitro. The studies of antiproliferative activity and RXR
Inhibition of IκB kinase-β and anticancer activities of novel chalcone adamantyl arotinoids
Lorenzo, Paula,Alvarez, Rosana,Ortiz, Maria A.,Alvarez, Susana,Piedrafita, F. Javier,De Lera, ángel R.
supporting information; experimental part, p. 5431 - 5440 (2009/07/01)
On the basis of the observations that chalcone 7 (MX781) and some related adamantyl arotinoids (AdArs) inhibit IκBα kinase β (IKKβ) activity, inhibit cell growth, and induce apoptosis in cancer cells, a new series of AdArs structurally related to 7 have b
Adamantyl-substituted biaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
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, (2008/06/13)
Novel pharmaceutically/cosmetically-active adamantyl-substituted biaromatic compounds have the structural formula (I): STR1 wherein Ar is a radical having one of the formulae (a')-(f'): STR2 and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Adamantyl-substituted polycyclic acetylene compounds and pharmaceutical/cosmetic compositions comprised thereof
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, (2008/06/13)
Novel pharmaceutically/cosmetically-active adamantyl-substituted polycyclic acetylene compounds have the structural formula (I): STR1 wherein Ar is a radical having one of the formulae (a)-(f): STR2 and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
