1732-46-3

Usage

Structure

It is a derivative of isothiazolecarboxylic acid with a phenyl group attached to the 5-position of the isothiazole ring.

Biological Activities

Antibacterial: Exhibits antibacterial properties.
Antifungal: Demonstrates antifungal activity.
Anti-inflammatory: Shows anti-inflammatory properties.

Heterocyclic Nature

It is a heterocyclic compound with an isothiazole ring containing a sulfur atom.

Potential Pharmaceutical Applications

It can serve as a valuable building block for the synthesis of various medicinal drugs and bioactive molecules.

Research Tool

It can be used as a research tool for studying the structure-activity relationships of isothiazole derivatives in drug discovery and development.

Upstream product

• 32551-26-1 5-phenyl-isothiazole-3-carboxylic acid methyl ester 
• 60027-35-2 4-phenyl-1,3,2-oxathiazolylium-5-olate 

Relevant academic research and scientific papers

AMIDO-ISOTHIAZOLE COMPOUNDS AND THEIR USE AS INHIBITORS OF 11BETA-HSD1 FOR THE TREATMENT OF METABOLIC SYNDROME AND RELATED DISORDERS

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-isothiazole compounds that, inter alia, inhibit 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.