17327-22-9

Basic information

• Product Name: 5,6-DIHYDRO-4-METHOXY-2H-PYRAN
• Synonyms: 5,6-DIHYDRO-4-METHOXY-2H-PYRAN;4-METHOXY-5,6-DIHYDROPYRAN;2H-Pyran, 3,6-dihydro-4-methoxy-;4-Methoxy-3,6-dihydro-2H-pyran;3,6-dihydro-4-methoxy-2H-pyran;5,6-Dihydro-4-methoxy-2H-pyrane;4-Methoxy-5,6-dihydro-2H-pyran;5,6-Dihydro-4-methoxy-2H-pyran ,95%
• CAS NO: 17327-22-9
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.14
• EINECS: 241-348-5
• Mol File: 17327-22-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 59 °C20 mm Hg(lit.)
• Flash Point: 116 °F
• Appearance: /
• Density: 1.022 g/mL at 25 °C(lit.)
• Vapor Pressure: 3.07mmHg at 25°C
• Refractive Index: n20/D 1.462(lit.)
• BRN: 1341205
• CAS DataBase Reference: 5,6-DIHYDRO-4-METHOXY-2H-PYRAN(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DIHYDRO-4-METHOXY-2H-PYRAN(17327-22-9)
• EPA Substance Registry System: 5,6-DIHYDRO-4-METHOXY-2H-PYRAN(17327-22-9)

Safety Data

• Statements: 10
• Safety Statements: 23-24/25
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 17327-22-9(Hazardous Substances Data)

Usage

Uses

5,6-Dihydro-4-methoxy-2H-pyran was used in solid-phase synthesis of series of oligoribonucleotides. It was also used as reagent for the protection of chiral alcohols.

General Description

5,6-Dihydro-4-methoxy-2H-pyran is suitable reagent for protection of nucleoside hydroxyl functions.

InChI:InChI=1/C6H10O2/c1-7-6-2-4-8-5-3-6/h2H,3-5H2,1H3

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 28218-71-5 4,4-dimethoxytetrahydro-4H-pyran 

Downstream Products

• 201860-64-2 2-O-(4-Methoxytetrahydropyran-4-yl)-myo-inositol 
• 120853-35-2 C₆₇H₆₁ClN₉O₁₄P 
• 80186-08-9 C₇₀H₇₂ClN₆O₁₉P 
• 120853-25-0 2,4,6-Trimethyl-benzenesulfonic acid 2-amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl ester 
• 120881-22-3 O⁶-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-N²-<<(9-fluorenylmethyl)oxy>carbonyl>-2'-O-(4-methoxytetrahydropyran-4-yl)guanosine 
• 624734-19-6 3-fluorodihydro-2H-pyran-4(3H)-one 
• 155834-46-1 N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine 
• 155834-45-0 N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 115561-35-8 {9-[(2R,3S,4R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[(4-methoxy-phenyl)-diphenyl-methyl]-amine 
• 80235-20-7 2'-O-(4-methoxytetrahydropyran-4-yl)-N²-diphenylacetylguanosine 
• 155834-44-9 N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine 
• 77451-34-4 5'-O-(o-dibromomethylbenzoyl)-2'-O-methoxytetrahydropyranyl-6-N-benzoyladenosine 
• 77451-35-5 N⁴-benzoyl-2'-O-(4-methoxytetrahydropyran-4-yl)cytidine 
• 86610-78-8 3'-O-(4-methoxytetrahydropyran-2-yl)-5'-O-<4,4',4''-tris(benzoyloxy)trityl>thymidine 

Relevant articles and documents

SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Efficient preparation of 4-methoxy-5,6-dihydro-2H-pyran

We report the efficient synthesis of 4-methoxy-5,6-dihydro-2H-pyran (MDHP) via the TiCl4 driven elimination of MeOH from 4,4-dimethoxytetrahydropyran. The previous difficulty of preparing MDHP restricted the wider use of 4-methoxytetrahydropyran-4-yl (MTHP) acyclic acetals, which have desirable protecting group properties when compared to more commonly used MOM- and THP-acetals. The behaviour of the elimination on related acetals is also examined.