173273-98-8Relevant academic research and scientific papers
A highly efficient synthesis of fibrinogen receptor antagonist L-734,217 via a novel chemoselective silyl-mediated conjugate addition of δ-lactams to 4-vinylpyridine
Chung, John Y. L.,Hughes, David L.,Zhao, Dalian,Song, Zhiguo,Mathre, David J.,Ho, Guo-Jie,McNamara, James M.,Douglas, Alan W.,Reamer,Tsay, Fuh-Rong,Varsolona, Richard,McCauley, James,Grabowski, Edward J. J.,Reider, Paul J.
, p. 215 - 222 (1996)
A highly practical chromatography-free six-step synthesis of L-734,217 suitable for large scale preparation is described. The key chiral pyridine acid intermediate (R)-1 was prepared in four steps based on a novel chemoselective silyl-mediated conjugate a
