173281-01-1

Basic information

• Product Name: 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID ETHYL ESTER;ethyl 2-aMino-5,7-dihydro-4H-thieno[2,3-c]thiopyran-3-carboxylate;ethyl 2-amino-4H,5H,7H-thieno[2,3-c]thiopyran-3-carboxylate
• CAS NO: 173281-01-1
• Molecular Formula: C₁₀H₁₃NO₂S₂
• Molecular Weight: 243.35
• Mol File: 173281-01-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 86-88 °C(Solv: methanol (67-56-1))
• Boiling Point: 460.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.337±0.06 g/cm3(Predicted)
• PKA: 0.25±0.20(Predicted)
• CAS DataBase Reference: 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID ETHYL ESTER(173281-01-1)
• EPA Substance Registry System: 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID ETHYL ESTER(173281-01-1)

Safety Data

• Hazardous Substances Data: 173281-01-1(Hazardous Substances Data)

Usage

General Description

2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID ETHYL ESTER is a chemical compound with the molecular formula C11H13NO4S2. It is an ethyl ester derivative of thieno[2,3-c]thiopyran-3-carboxylic acid, containing an amino group and a carboxylic acid group. 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID ETHYL ESTER has potential biological and pharmacological activities and has been studied for its potential applications in the pharmaceutical industry. It may possess anti-inflammatory, antioxidant, and neuroprotective properties, and its chemical structure makes it a valuable candidate for further research and development in drug discovery and medicinal chemistry.

Upstream product

• 10292-84-9 ethyl 2-cyano-2-(2H-thiopyran-4(3H,5H,6H)-ylidene)acetate 
• 4131-74-2 Dimethyl 3,3'-thiodipropionate 
• 4160-61-6 3-methoxycarbonyltetrahydropyran-4-one 
• 1072-72-6 Tetrahydrothiopyran-4-one 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 1180526-91-3 ethyl 2-[(triphenylphosphanylidene)amino]-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylate 

Relevant articles and documents

New Hetero-Annelation Reactions Using N-[bis-(Methylthio)-methylene]-amino and Related Reagents

Reaction of acyclic (R1-3) and cyclic (R4-5) BMMA (=N-[bis-(methylthio)-methylene]-amino) reagents with Gewald-type thiophene derivatives (2, 3) led to annelation of pyrimidine moieties. Thus, linear thiazolo- or thiazino- and pyrrolo-, pyrido- or azepino-fused thiopyrano[4′,3′:4,5]thieno-[2,3-d]pyrimidines (5 and 6) as well as the angular imidazo-fused thiopyrano[4′,3′:4,5]thieno-[2,3-d]pyrimidine 8 were easily obtained from one-pot reactions in good yields.

Aqueous DABCO, an efficient medium for rapid organocatalyzed Knoevenagel condensation and the Gewald reaction

In the presence of water and 1,4-diazabicyclo[2.2.2]octane, several aldehydes and cyclic ketones underwent efficient Knoevenagel condensation with malononitrile and ethyl cyanoacetate to produce the respective α.β-unsaturated systems within fairly short time periods. As a result, high yields of conjugated products were easily obtained. Products could be engaged in a Gewald reaction, either stepwise or in situ, to produce efficiently their respective 2-aminothiophenes within 4-7 h. TUeBITAK.

THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C

The present invention provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts h

Efficient synthesis and fungicidal activities of 3,5,6,8-tetrahydro-4h- thiopyrano[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ones

The carbodiimides 4, obtained from reactions of iminophosphorane 3 with aromatic isocyanates, reacted with amines, phenols, or ROH to give 2-substituted 3,5,6,8-tetrahydro-4H-thiopyrano[4′,3′ :4,5]thieno [2,3-d]pyrimidin-4-ones 6 in the presence of a catalytic amount of sodium alkoxide or solid potassium carbonate in satisfactory yields. Compounds 6 exhibited fungicidal activity. For example, compounds 6e, 6m, and 6s showed 70% inhibition activities against Dothiorella gregaria in 100 mg/L.