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Usage

Uses

Used in Pharmaceutical Research:
Z-TYR-LEU-NH2 is used as a model compound for studying the interactions of peptides with biological systems, which is crucial for understanding their behavior and potential therapeutic effects.
Used in Drug Development:
Z-TYR-LEU-NH2 is utilized as a template in the development of peptide-based drugs, providing insights into the structural requirements for biological activity.
Used in Neurotransmitter Modulation Research:
Z-TYR-LEU-NH2 is used as a research tool to explore its potential role in modulating neurotransmitter activity, which could have implications for the treatment of neurological disorders.
Used in Therapeutic Agent Development for Neurological Disorders:
Z-TYR-LEU-NH2 is considered as a potential therapeutic agent for conditions such as neurological disorders, given its effects on neurotransmitter activity.
Used in Therapeutic Agent Development for Chronic Pain:
Z-TYR-LEU-NH2 is also being studied for its potential as a therapeutic agent for chronic pain, suggesting that it may have analgesic properties.
Used in Structure-Activity Relationship Studies:
Z-TYR-LEU-NH2 is used in research to determine the relationship between the chemical structure of peptides and their biological activities, which is vital for the design of effective peptide-based drugs.

Upstream product

• 15893-47-7 (R)-2-amino-4-methylpentanamide 
• 16679-94-0 N-[(phenylmethoxy)carbonyl]-L-tyrosine 
• 687-51-4 H-L-Leu-NH₂ 
• 1164-16-5 Z-L-Tyr-OH 
• 13512-31-7 N-(benzyloxycarbonyl)-L-tyrosine methyl ester 
• 1668-11-7 2-Amino-4-methyl-pentanoic acid amide; hydrochloride 
• 13512-31-7 2-Benzyloxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Studies on Enzymatic Peptide Synthesis in Biphasic Aqueous-Organic Systems with Product Extraction

The dipeptide derivatives Z-Tyr-Leu-NH2 and Mca-Tyr-Leu-NH2 were synthesized by α-chymotrypsin-catalyzed coupling reactions in solvent systems consisting of buffer and ethyl acetate.In comparison to a pure aqueous medium, in which only insignificant synth

ENZYME PEPTIDE SYNTHESIS BY AN ITERATIVE PROCEDURE IN A NUCLEOPHILE POOL

An effective method for enzyme solubility-controlled synthesis of peptides, consisting in an iterative addition of equivalent amounts of acyl and amine components to a solution(nucleophile pool) containing the enzyme and a large excess of the amine component, is described.

Enzymatic C-terminal amidation of amino acids and peptides

Herein, we describe two versatile and high yielding enzymatic approaches for the conversion of semi-protected amino acid and peptidyl C-terminal α-carboxylic acids into their corresponding amides. In the first approach, the lipase Candida antarctica lipase-B (Cal-B), and in the second approach, the protease Subtilisin A, are used, respectively. We found that by using the ammonium salt of the α-carboxylic acid instead of separate ammonia sources, the enzymatic amidation reactions proceeded much faster without side reactions and gave near to quantitative yields of products.