173321-72-7Relevant academic research and scientific papers
Weakly ligated palladium complexes PdCl2(RCN)2 in piperidine: Versatile catalysts for Sonogashira reaction of vinyl chlorides at room temperature
Alami, Mouad,Crousse, Benoit,Ferri, Fabiola
, p. 114 - 123 (2001)
Copper iodide and weakly ligated palladium complexes PdCl2(RCN)2 (R = Ph, Me) catalyzed efficiently the coupling reaction of vinyl chlorides with 1-alkynes in the presence of piperidine to give the corresponding conjugated enynes in good to excellent yields. The reaction takes place rapidly and cleanly at room temperature. Application to the synthesis of terbinafine which exhibits strong antimycotic activity has been realized.
A two-step synthesis of terbinafine
Alami, Mouad,Ferri, Fabiola,Gaslain, Yann
, p. 57 - 58 (1996)
An efficient and high yielding synthesis of terbinafine 1a and amino enyne derivatives 1b-f is described from amino vinyl chlorides 2a-b and 1-alkynes in the presence of a weak ligated palladium complex: PdCl2(PhCN)2 in piperidine.
