173336-49-7Relevant academic research and scientific papers
Structural modification of the P2′ position of 2,7-dialkyl- substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: The discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets
Maibaum, Jürgen,Stutz, Stefan,G?schke, Richard,Rigollier, Pascal,Yamaguchi, Yasuchika,Cumin, Frédéric,Rahuel, Joseph,Baum, Hans-Peter,Cohen, Nissim-Claude,Schnell, Christian R.,Fuhrer, Walter,Gruetter, Markus G.,Schilling, Walter,Wood, Jeanette M.
, p. 4832 - 4844 (2008/03/12)
Due to its function in the rate limiting initial step of the renin-angiotensin system, renin is a particularly promising target for drugs designed to control hypertension, a growing risk to health worldwide. Despite vast efforts over more than two decades
METHODS OF TREATING ALZHEIMER'S DISEASE USING ARYL ALKANOIC ACID AMIDES
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Page 246-247, (2010/02/05)
Disclosed are methods for treating Alzheimer’s disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula 1 (1) wherein the variables R1-R8 and X are defined herein.
