173336-82-8 Usage
Uses
Used in Pharmaceutical Industry:
2-(Ethylsulfonyl)ethanamine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to participate in amine and sulfone functional group transformations. Its versatility in organic synthesis allows for the creation of a broad spectrum of medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Ethylsulfonyl)ethanamine serves as a crucial component in the development of new agrochemicals, contributing to the production of effective and innovative products for agricultural applications.
Used in Material Science:
2-(Ethylsulfonyl)ethanamine is utilized in the development of new materials due to its unique chemical properties, which can enhance the performance characteristics of various materials in different industries.
Used in Medicinal Chemistry Research:
2-(Ethylsulfonyl)ethanamine is also employed in medicinal chemistry research as a valuable tool for exploring new drug candidates and understanding the mechanisms of action of existing pharmaceuticals, given its potential to be modified and incorporated into diverse molecular structures.
Check Digit Verification of cas no
The CAS Registry Mumber 173336-82-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,3,3 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 173336-82:
(8*1)+(7*7)+(6*3)+(5*3)+(4*3)+(3*6)+(2*8)+(1*2)=138
138 % 10 = 8
So 173336-82-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H11NO2S/c1-2-8(6,7)4-3-5/h2-5H2,1H3
173336-82-8Relevant academic research and scientific papers
Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl- octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin
G?schke, Richard,Stutz, Stefan,Rasetti, Vittorio,Cohen, Nissim-Claude,Rahuel, Joseph,Rigollier, Pascal,Baum, Hans-Peter,Forgiarini, Peter,Schnell, Christian R.,Wagner, Trixie,Gruetter, Markus G.,Fuhrer, Walter,Schilling, Walter,Cumin, Frédéric,Wood, Jeanette M.,Maibaum, Jürgen
, p. 4818 - 4831 (2008/03/13)
The action of renin is the rate-limiting step of the renin-angiotensin system (RAS), a key regulator of blood pressure. Effective renin inhibitors directly block the RAS entirely at source and, thus, may provide a vital weapon for hypertension therapy. Our efforts toward identifying novel small-molecule peptidomimetic renin inhibitors have resulted in the design of transition-state isosteres such as 1 bearing an all-carbon 8-phenyl-octanecarboxamide framework. Optimization of the extended P3 portion of 1 and extensive P2′ modifications provided analogues with improved in vitro potencies in the presence of plasma. X-ray resolution of rh-renin/38a in the course of SAR work surprisingly unveiled the exploitation of a previously unexplored pocket (S3sp) important for strong binding affinities. Several inhibitors demonstrated oral efficacy in sodium-depleted marmosets. The most potent, 38a, induced dose-dependently a pronounced reduction in mean arterial blood pressure, paralleled by complete blockade of active plasma renin, up to 8 h post-dose. Oral bioavailability of 38a was 16% in marmosets.
