17336-69-5Relevant academic research and scientific papers
Beta-sulfonyl hydrazone derivative and preparation method and application thereof
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Paragraph 0039; 0053-0057, (2021/01/20)
The invention discloses a beta-sulfuryl hydrazone derivative and a preparation method and application thereof. The preparation method comprises the following steps: taking alpha-azido ketone and sulfonyl hydrazine as initial raw materials, taking CuSO4.5H2O as a catalyst, taking water as a reaction solvent, and reacting at 80 DEG C for 2-4 hours. According to the method, the catalyst CuSO4.5H2O isused in a reaction system, so that the reaction is effectively promoted, the self-coupling reaction of sulfonyl hydrazine is inhibited, and the reaction yield is increased; meanwhile, used reaction reagents and catalysts are stable, cheap and easy to obtain, large-batch production is facilitated, and a new effective way is provided for constructing the structure; and the reaction solvent is water, so that the advantages of greenness, economy and environmental protection are acheived. Therefore, the method has the characteristics of low cost, economy, environmental protection, high efficiency,wide functional group applicability and the like, and the beta-sulfuryl hydrazone compound is a widely used reaction intermediate. In addition, an activity experiment result shows that the product shows a certain degree of tumor inhibition activity.
