1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil, also known as FIAU, is a synthetic nucleoside analog with antiviral and antineoplastic properties. It has been utilized in medical research as a radioiodinated agent for the treatment of cancer and viral infections. FIAU selectively targets and disrupts the replication of specific DNA viruses, making it a promising candidate for the treatment of herpes simplex virus and hepatitis B virus. Additionally, it is being explored for its potential in gene therapy and imaging applications. However, its application has been restricted due to concerns regarding toxicity and the potential for resistance development.
173379-67-4
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Basic information
- Product Name: 1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil
- Synonyms: 1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil
- CAS NO:173379-67-4
- Molecular Formula:
- Molecular Weight: 397.104
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil(CAS DataBase Reference)
- NIST Chemistry Reference: 1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil(173379-67-4)
- EPA Substance Registry System: 1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil(173379-67-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 173379-67-4(Hazardous Substances Data)
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173379-67-4 Usage
Uses
Used in Antiviral Applications:1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil is used as an antiviral agent for targeting and disrupting the replication of certain DNA viruses, such as herpes simplex virus and hepatitis B virus. Its selective action against these viruses has shown promise in preclinical studies, making it a potential treatment option.
Used in Antineoplastic Applications:
In the field of oncology, 1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil is used as an antineoplastic agent. Its antiviral properties have been leveraged to target and inhibit the growth of cancer cells, offering a potential therapeutic approach for cancer treatment.
Used in Gene Therapy:
1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil is used as a component in gene therapy applications. Its unique properties allow for the manipulation of genetic material, providing a means to address genetic disorders and diseases at the molecular level.
Used in Imaging Applications:
In the medical imaging industry, 1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil is used as a contrast agent for enhancing the visualization of specific biological processes and structures. Its radioiodinated nature allows for improved imaging of viral infections and cancerous tissues, aiding in the diagnosis and monitoring of disease progression.
Check Digit Verification of cas no
The CAS Registry Mumber 173379-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,3,7 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.Calculate Digit Verification of CAS Registry Number 173379-67:
(8*1)+(7*7)+(6*3)+(5*3)+(4*7)+(3*9)+(2*6)+(1*7)=164
164 % 10 = 4
So 173379-67-4 is a valid CAS Registry Number.
173379-67-4Upstream product
173379-67-4Downstream Products
- 1145869-36-8 1-(4'-azido-3'-O-benzoyl-2'-deoxy-2'-fluoro-5'-iodo-β-D-arabinofuranosyl)uracil
- 1333126-30-9 1-(4-azido-2-deoxy-2-fluoro-3-O-benzoyl-5-O-(3-chlorobenzoyl)-β-D-arabinofuranosyl)uracil
- 1360459-69-3 C25H21ClFN7O7
- 1360459-70-6 C28H25ClFN7O9
- 1360459-71-7 C29H26ClFN6O8
- 1360459-72-8 C27H24ClFN6O8
- 1360459-73-9 C33H28ClFN6O8
- 1360459-74-0 2'-doxy-2'-β-fluoro-4'-azido-3'-O-benzoyl-5'-O-(m-chlorobenzoyl)uridine
- 1360459-42-2 2'-doxy-2'-β-fluoro-4'-azido-3'-O-benzoyl-5'-O-(m-chlorobenzoyl)uridine
- 1360459-75-1 2'-doxy-2'-β-fluoro-4'-azido-3'-O-benzoyl-5'-O-(m-chlorobenzoyl)uridine
- 1360459-77-3 2'-doxy-2'-β-fluoro-4'-azido-3'-O-benzoyl-5'-O-(m-chlorobenzoyl)uridine
- 1360459-78-4 2'-doxy-2'-β-fluoro-4'-azido-3'-O-benzoyl-5'-O-(m-chlorobenzoyl)uridine
- 1360459-58-0 C38H39ClFN5O9S
- 1360459-59-1 C27H24ClFN6O8
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1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil
