173379-73-2Relevant academic research and scientific papers
Azido nucleosides and nucleotide analogs
-
Page/Page column 100; 101, (2016/06/13)
Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
3-methyl uridine and 4-methyl cytidine nucleoside compound, synthetic method and its pharmaceutical use
-
Paragraph 0025; 0057, (2016/10/08)
The invention discloses a 3-methyluridine and 4-methylcytidine nucleosides compound and a synthesis method and pharmaceutical application thereof, belonging to the field of medicinal chemistry. The compound has a structural formula as shown in the specification. The compound has the effects of simultaneously modifying sugar rings and basic groups, increasing the activity of the compound and reducing the toxicity, provides a good application prospect for development of like medicines and can be applied to preparation of anti-HBV (Hepatitis B virus) medicines. The synthesis method is simple and feasible and provides conditions for mass synthesis of the compound.
Synthesis and biological evaluation of 4-substituted fluoronucleoside analogs for the treatment of hepatitis B virus infection
Yang, Qinghua,Kang, Jinfeng,Zheng, Liyun,Wang, Xue-Jun,Wan, Na,Wu, Jie,Qiao, Yan,Niu, Pengfei,Wang, Sheng-Qi,Peng, Youmei,Wang, Qingduan,Yu, Wenquan,Chang, Junbiao
supporting information, p. 3693 - 3703 (2015/05/27)
A series of 4-substituted fluoronucleosides have been synthesized in order to address the toxicity issue of the parent compound 7, and after in vitro evaluation, the cyclopropylamino analog 1f was selected for in vivo study. In mice, this compound exhibit
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4′-azidocytidine against hepatitis C virus replication: The discovery of 4′-azido-2′-deoxy-2′-fluorocytidine and 4′-azido-2′-dideoxy-2′,2′-difluorocytidine
Smith, David B.,Kalayanov, Genadiy,Sund, Christian,Winqvist, Anna,Maltseva, Tatiana,Leveque, Vincent J.-P.,Rajyaguru, Sonal,Le Pogam, Sophie,Najera, Isabel,Benkestock, Kurt,Zhou, Xiao-Xiong,Kaiser, Ann C.,Maag, Hans,Cammack, Nick,Martin, Joseph A.,Swallow, Steven,Johansson, Nils Gunnar,Klumpp, Klaus,Smith, Mark
experimental part, p. 2971 - 2978 (2010/02/28)
The discovery of 4′-azidocytidine (3) (R1479) (J. Biol. Chem. 2006, 281, 3793; Bioorg. Med. Chem. Lett. 2007, 17, 2570) as a potent inhibitor of RNA synthesis by NS5B (EC50 = 1.28 μM), the RNA polymerase encoded by hepatitis C virus (HCV), has led to the
2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS
-
Page/Page column 64; 66, (2009/06/27)
Embodiments of the invention are to compounds of formulae (A), (A'), methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention aur 2 ', 4 ' -substituted nucleoside compounds useful for the treat
