173382-28-0

Basic information

• Product Name: 2-THIAZOLYLZINC BROMIDE
• Synonyms: 2-THIAZOLYLZINC BROMIDE;2-THIAZOLYLZINC BROMIDE, 0.5M SOLUTION I N TETRAHYDROFURAN;2-thiazolylzinc bromide solution;2-Thiazolylzinc bromide solution 0.5 in THF;2-Thiazolylzinc broMide, 0.5M in THF, packaged under Argon in resealable CheMSeal^t bottles;thiazol-2-ylzinc(II) broMide;2-Thiazolylzinc broMide solution 0.5 M in THF;2-Thiazolylzinc bromide, 0.5M in THF, packaged under Argon in resealable ChemSeal™
• CAS NO: 173382-28-0
• Molecular Formula: C₃H₂BrNSZn
• Molecular Weight: 229.41
• Product Categories: Alkyl;Organozinc Halides;Reike and Organozinc Reagents;Chemical Synthesis;Heteroaryl;Organometallic Reagents;Organozinc Halides;Rieke and Organozinc Reagents
• Mol File: 173382-28-0.mol
• Article Data: 6

Chemical Properties

• Flash Point: 1 °F
• Appearance: Yellow to brown to black/Liquid
• Density: 0.992 g/mL at 25 °C
• Storage Temp.: 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-THIAZOLYLZINC BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-THIAZOLYLZINC BROMIDE(173382-28-0)
• EPA Substance Registry System: 2-THIAZOLYLZINC BROMIDE(173382-28-0)

Safety Data

• Hazard Codes: F,Xn,C
• Statements: 14-19-22-36/38-40-37-34-11
• Safety Statements: 16-26-33-36-45-36/37/39
• RIDADR: UN 2056 3/PG 2
• WGK Germany: 1
• HazardClass: 4.3
• Hazardous Substances Data: 173382-28-0(Hazardous Substances Data)

Usage

Description

2-Thiazolylzinc bromide is a chemical compound that features a zinc atom bonded to a 2-thiazolyl ring and a bromine atom. It is recognized for its nucleophilic properties in organic reactions, which are instrumental in the formation of carbon-carbon and carbon-heteroatom bonds. 2-THIAZOLYLZINC BROMIDE is a versatile and reactive intermediate in organic synthesis, widely used in both academic and industrial settings.

Uses

Used in Organometallic Chemistry:
2-Thiazolylzinc bromide is used as a reagent in organometallic chemistry for its ability to participate in various organic reactions, facilitating the creation of new chemical bonds and structures.
Used in Pharmaceutical Research and Drug Discovery:
In the pharmaceutical industry, 2-Thiazolylzinc bromide is utilized as a building block for the synthesis of new bioactive molecules. Its role in the development of potential drug candidates is significant, contributing to the advancement of medicinal chemistry.
Used in Academic Research:
2-Thiazolylzinc bromide is employed in academic laboratories for the study of organic synthesis and the exploration of new reaction mechanisms, furthering the understanding of chemical bond formations and the properties of organometallic compounds.
Used in Industrial Laboratories:
2-THIAZOLYLZINC BROMIDE is also used in industrial applications for the large-scale synthesis of complex organic compounds, contributing to the production of specialty chemicals and pharmaceuticals.

InChI:InChI=1/C3H2NS.BrH.Zn/c1-2-5-3-4-1;;/h1-2H;1H;/q;;+1/p-1/rC3H2BrNSZn/c4-7-3-5-1-2-6-3/h1-2H

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 7440-66-6 zinc 

Downstream Products

• 880885-42-7 2-amino-4-methoxy-6-thiazol-2-yl-benzonitrile 
• 1016544-67-4 (2-fluoro-5-(thiazol-2-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone 
• 1616930-60-9 C₁₇H₁₇N₃O₂S 
• 1616930-44-9 C₁₆H₁₅N₃O₂S 
• 1616930-34-7 C₁₇H₁₇N₃O₃S 
• 1613301-03-3 {(S)-6-[(R)-7-fluoro-4-(4-thiazol-2-ylphenoxy)indan-1-yloxy]-2,3-dihydrobenzofuran-3-yl}acetic acid methyl ester 
• 1608482-80-9 2-(4-chloro-6-(4-isopropoxyphenyl)pyridin-2-yl)thiazole 
• 1458656-32-0 2-(4-bromo-3,5-dimethyl-phenyl)-thiazole 
• 1373756-55-8 tert-butyl (2S,3S)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-1-(3-(thiazol-2-yl)phenyl)butan-2-ylcarbamate 
• 1372540-82-3 2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-4-(1,3-thiazol-2-yl)-1H-benzimidazole 
• 1360608-59-8 8-(1,3-thiazol-5-yl)-N-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5a]pyrazin-2-amine 
• 1036743-26-6 5-Chloro-N-(4-morpholinophenyl)-6-(thiazole-2-yl)quinazolin-2-amine 
• 1036744-70-3 N-(4-morpholinophenyl)-5,6-di(thiazole-2-yl)quinazolin-2-amine 
• 1036752-81-4 N-(3-(6-(thiazol-2-yl)quinazolin-2-ylamino)phenyl)acetamide 

Relevant articles and documents

ALTERNATIVE PROCESS FOR THE PREPARATION OF 4-PHENYL-5-ALKOXYCARBONYL-2-THIAZOL-2-YL-1,4-DIHYDROPYRIMIDIN-6-YL]METHYL]-3-OXO-5,6,8,8A-TETRAHYDRO-1H-IMIDAZO[1,5-A]PYRAZIN-2-YL]-CARBOXYLIC ACID

The present invention relates to an alternative process for synthesizing a compound of formula (I), R1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and C1-6alkyl; R2 is C1-6alkyl; R3 is -CxH2x-; x is 1, 2, 3, 4, 5, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.

THIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF

The present invention relates to thiazole compounds of formula I , the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses

HEDGEHOG PATHWAY SIGNALING INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF

The hedgehog (Hh) signaling pathway is a pathway which regulates patterning, growth and cell migration during embryonic development, but in adulthood is limited to tissue maintenance and repair. Mutational inactivation of the inhibitory pathway components leads to constitutive ligand-independent activation of the Hh signaling pathway, results in cancers such as basal cell carcinoma and medulloblastoma. Ligand-dependent activation of Hh signaling is involved in prostate cancer, pancreatic cancer, breast cancer and blood cancers. Therefore, inhibition of the aberrant Hh signaling represents a promising approach toward novel anticancer therapy. The invention provides novel molecules of formula I that inhibit hedgehog pathway signaling and provides therapeutic applications for the treatment of malignancies (basal cell carcinoma, medulloblastoma, glioblastoma, non-small cell lung cancer, prostate cancer, pancreatic cancer, blood cancers, mesenchymal cancers, etc.), prevention of tumor regrowth, sensitization of radio-chemo therapies, and other diseases (inflammation, fibrosis and immune disorders).