173416-05-2 Usage
Reaction
Widely used in complex multi-step organic syntheses. This mild hydration catalyst converts hindered and acid/base sensitive nitriles to amides. The amide is released from the metal coordination sphere preventing further hydrolysis to acid. Typically, turnover frequency (TOF) ranges from 16 to 380 h-1 depending on steric factors. For optimal results avoid the presence of coordinating anions especially cyanide and halide.
Uses
Parkins’ Catalyst promotes the efficient nitriles hydration to amides by the phosphine oxide addition to nitrile.
Check Digit Verification of cas no
The CAS Registry Mumber 173416-05-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,4,1 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 173416-05:
(8*1)+(7*7)+(6*3)+(5*4)+(4*1)+(3*6)+(2*0)+(1*5)=122
122 % 10 = 2
So 173416-05-2 is a valid CAS Registry Number.
173416-05-2Relevant articles and documents
MENIN INHIBITORS AND METHODS OF USE FOR TREATING CANCER
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Paragraph 00604-00605, (2021/10/15)
The present disclosure provides compounds represented by Formula (I), or a pharmaceutically acceptable salt thereof, wherein Ra, Rb, Rc, Rd, V, Q, T, n, p, q, r and s are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat cancer or any other disease, condition, or disorder that is responsive to inhibition of menin.
