173429-65-7

Basic information

• Product Name: L-NAFADOTRIDE
• Synonyms: L-NAFADOTRIDE;2-Naphthalenecarboxamide tartrate, (-)-N[n-butyl-2-pyrrolidinyl)methyl]-1-methoxy-4-cyanonaphthalene-2-carboxamide tartrate
• CAS NO: 173429-65-7
• Molecular Formula: C22H27N3O2.C4H6O6
• Molecular Weight: 515.56
• Mol File: 173429-65-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 760.1°C at 760 mmHg
• Flash Point: 413.5°C
• Appearance: white/solid
• Vapor Pressure: 2.74E-24mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: H2O: ~9 mg/mL, soluble
• CAS DataBase Reference: L-NAFADOTRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: L-NAFADOTRIDE(173429-65-7)
• EPA Substance Registry System: L-NAFADOTRIDE(173429-65-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 173429-65-7(Hazardous Substances Data)

Usage

Uses

(-)-Nafadotride is a potent preferential dopamine D2 and D3 receptor antagonist in rodents.

InChI:InChI=1/C22H27N3O2.C4H6O6/c1-3-4-11-25-12-7-8-17(25)15-24-22(26)20-13-16(14-23)18-9-5-6-10-19(18)21(20)27-2;5-1(3(7)8)2(6)4(9)10/h5-6,9-10,13,17H,3-4,7-8,11-12,15H2,1-2H3,(H,24,26);1-2,5-6H,(H,7,8)(H,9,10)/t17-;1-,2-/m00/s1

Relevant articles and documents

NAPHTHAMIDE DERIVATIVES

The new naphthamide derivatives according to the invention are characterized in that they correspond to the general formula (I), STR1 where X: represents either a hydrogen atom, or a chlorine or bromine atom, or an amino or aminoalkyl group, an aminosulphamoyl group, a sulphur-containing group such as thiocyanate, alkylthio, alkylsulphinyl or alkylsulphonyl, or a methoxy group, or a nitro group, or a cyano group, or an electron-attracting group;Y: represents an alkyl or alkenyl residue;Z: represents the residues originating from 2-aminomethyl-N-alkylpyrrolidine, 2-aminoethyl-N,N-diethylamine, 2-(aminoethyl)morpholine, 2-aminoethyl-N,N-dibutylamine, 4-amino-N-butylpiperidine or 2-(aminoethyl)pyrrolidine;R: a hydrogen or an OCH 3 substituent.These new derivatives may be employed in the preparation of medicinal products intended for use as an antipsychotic, psychostimulatory, anti-autistic or antidepressant agent, an agent for treating Parkinson's disease or an antihypertensive agent.