173440-20-5

Upstream product

• 167865-74-9 tert-butyl(diphenyl)silylethene 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 845786-38-1 tert-butyl-[2-(2,6-dimethyl-phenoxy)-ethyl]-diphenyl-silane 
• 845786-35-8 {2-[2-(tert-butyl-diphenyl-silanyl)-ethoxy]-phenyl}-acetic acid methyl ester 
• 845786-40-5 2-tert-butoxycarbonylamino-3-{4-[2-(tert-butyl-diphenyl-silanyl)-ethoxy]-phenyl}-propionic acid benzyl ester 
• 845786-31-4 N-t-Boc-O-t-butyldiphenylsilylethyl-3-iodo-(L)-tyrosine benzyl ester 
• 845786-37-0 {3-bromo-2-[2-(tert-butyl-diphenyl-silanyl)-ethoxy]-phenyl}-acetic acid methyl ester 
• 1161258-91-8 7-(2-(tert-butyldiphenylsilyl)ethoxy)-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one 
• 1227192-70-2 6-benzyloxy-4-[2-(tert-butyl-diphenyl-silanyl)-ethoxy]-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

ANTI-CD98 ANTIBODIES AND ANTIBODY DRUG CONJUGATES

The invention relates to anti-CD98 antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

ANTI-EGFR ANTIBODY DRUG CONJUGATES

The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.

BCL-XL Inhibitory Compounds and Antibody Drug Conjugates Including the Same

Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.

tert-buyldiphenylsilylethyl ("TBDPSE"): A practical protecting group for phenols

(Chemical Equation Presented) A new protection group for phenols, the 2-(tert-butyldiphenylsilyl)ethyl (TBDPSE) group, has been prepared and investigated. Protection of a variety of substituted phenols proceeds in good to excellent yield. The group is stable to mild acid, base, hydrogenolysis conditions, and lithium/ halogen exchange on the protected phenol. Removal is achieved with strong acid or standard fluoride treatment.