1735-91-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Nitro-4-(trifluoromethyl)phenylacetic acid is used as an intermediate in the production of pharmaceuticals for its anti-inflammatory and painkilling properties. It plays a crucial role in the synthesis of various medications that help alleviate pain and reduce inflammation.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Nitro-4-(trifluoromethyl)phenylacetic acid is utilized as an intermediate in the synthesis of agrochemicals. Its unique properties contribute to the development of effective products for agricultural applications.
Used as a Reagent in Organic Synthesis:
2-Nitro-4-(trifluoromethyl)phenylacetic acid is also used as a reagent in organic synthesis for the preparation of various compounds. Its versatility in chemical reactions makes it a valuable component in the synthesis of a wide range of organic compounds for different industries.

InChI:InChI=1/C9H6F3NO4/c10-9(11,12)6-2-1-5(3-8(14)15)7(4-6)13(16)17/h1-2,4H,3H2,(H,14,15)/p-1

Upstream product

• 13544-04-2 Ethyl 2-cyano-2-(2-nitro-4-(trifluoromethyl)phenyl)acetate 
• 98-56-6 4-chlorobenzotrifluoride 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 120542-04-3 tert-butyl 2-nitro-4-trifluoromethyl-phenylacetate 
• 32857-62-8 4-Trifluoromethylphenylacetic acid 
• 7664-93-9 sulfuric acid 
• 290825-52-4 dimethyl 2-(2-nitro-4-trifluoromethylphenyl)malonate 

Downstream Products

• 13544-07-5 methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate 
• 35318-52-6 2'-Nitro-4,4'-bis-(trifluormethyl)-α-phenylzimtsaeure 
• 38597-55-6 (E)-3-(3-Bromo-phenyl)-2-(2-nitro-4-trifluoromethyl-phenyl)-acrylic acid 
• 38635-67-5 (E)-2-(2-Nitro-4-trifluoromethyl-phenyl)-3-(3,4,5-tribromo-phenyl)-acrylic acid 
• 35318-48-0 4-Chlor-2'-nitro-4'-trifluormethyl-α-phenylzimtsaeure 
• 35318-45-7 2'-Nitro-4'-trifluormethyl-α-phenylzimtsaeure 
• 38635-54-0 (E)-3-(2,4-Dichloro-phenyl)-2-(2-nitro-4-trifluoromethyl-phenyl)-acrylic acid 
• 35318-47-9 4-Brom-2'-nitro-4'-trifluormethyl-α-phenylzimtsaeure 
• 35318-49-1 4-Iod-2'-nitro-4'-trifluormethyl-α-phenylzimtsaeure 
• 38597-53-4 (E)-3-(2-Bromo-phenyl)-2-(2-nitro-4-trifluoromethyl-phenyl)-acrylic acid 
• 294673-65-7 ethyl 4-[2-nitro-4-(trifluoromethyl)phenyl]-3-oxobutanoate 
• 38635-72-2 1-Bromo-6-trifluoromethyl-phenanthrene-9-carboxylic acid 
• 38635-85-7 1,3-dichloro-6-(trifluoromethyl)phenanthren-9-carboxylic acid 
• 35315-62-9 6-Trifluormethyl-phenanthren-9-carbonsaeure 

Relevant academic research and scientific papers

SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS

Disclosed herein are various methods for synthesizing compounds that modulate thrombopoietin activity. Also disclosed are intermediates useful for the preparation of these compounds.

Substituted indolinones, their manufacture and their use as medicaments

The present invention relates to substituted indolinones of general formula wherein R1to R6and X are defined as in claim 1, the isomers and the salts thereof, in particular the physiologically acceptable salts thereof which have valuable pharmacological properties, especially an inhibitory effect on various receptor-tyrosine kinases, and cycline/CDK complexes as well as on the proliferation of endothelial cells and various tumor cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

Kappa agonist compounds and pharmaceutical formulations thereof

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, IIA, III, IIIA, IIIB, IIIB-i, IV and IVA have the structure: wherein R1, R2, R3, R4; and X, X4, X5, X7, X9; Y, Z and n are as described in the specification.

Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith

Method for the prevention or treatment of pruritis by administering to a patient an antipruritic compound, or pharmaceutically acceptable salt thereof, of the class arylacetamide, which is exemplified by compounds of the formulae I, II, IIA, III, IV and IVA having the structures: and in which R1-4, X, X4, X5, X7, X9, Y and Z are as described in the specification.

Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formula I, having the structure: wherein R1, R2; X; and Ar Y, Z and n are as described in the specification.