173532-15-5

Usage

Uses

Used in Pharmaceutical Industry:
TIZANIDINE RELATED COMPOUND B (50 MG) (N-ACETYLTIZANIDINE) is used as a muscle relaxant for the treatment of muscle spasms and spasticity. It works by blocking pain sensations and aiding in muscle relaxation, providing relief to patients suffering from various muscle-related conditions.
Used in Neurological Applications:
In the field of neurology, TIZANIDINE RELATED COMPOUND B (50 MG) (N-ACETYLTIZANIDINE) is used to alleviate muscle stiffness and spasms associated with multiple sclerosis and spinal cord injuries. Its muscle relaxant properties help improve the quality of life for patients dealing with these conditions.
Used in Orthopedic Applications:
TIZANIDINE RELATED COMPOUND B (50 MG) (N-ACETYLTIZANIDINE) is also utilized in orthopedics to manage muscle-related pain and discomfort following surgeries or injuries. Its muscle relaxant action aids in faster recovery and reduces the risk of complications during the healing process.
Used in Pain Management:
In pain management, TIZANIDINE RELATED COMPOUND B (50 MG) (N-ACETYLTIZANIDINE) is employed to provide relief from chronic pain caused by muscle tension and spasms. Its muscle relaxant properties help in reducing pain and improving the overall well-being of patients suffering from chronic pain conditions.

InChI:InChI=1/C11H10ClN5OS/c1-6(18)17-5-4-13-11(17)14-9-7(12)2-3-8-10(9)16-19-15-8/h2-3H,4-5H2,1H3,(H,13,14)

Upstream product

• 5391-39-9 1-acetylimidazolidin-2-one 
• 30536-19-7 4-amino-5-chloro-2,1,3-benzothiadiazole 

Downstream Products

• 51322-75-9 tizanidine 

Relevant academic research and scientific papers

Preparation method of tizanidine hydrochloride

The invention discloses a preparation method of tizanidine hydrochloride, and belongs to the field of medicine preparation. According to the preparation method, 5-chloro-4-amino-2,1,3-benzothiadiazole and 1-acetyl-2-imidazolinone are taken as raw materials, and condensation, alcoholysis and salification are performed, further refining can be performed; then the tizanidine hydrochloride can be prepared. The operation is simpler, more convenient and safer, and the preparation method is more suitable for industrial production. The tizanidine hydrochloride prepared by the method is higher in yield, the obtained tizanidine hydrochloride is also higher in purity; the method has important industrial value, and can protect the supply of the bulk drug tizanidine hydrochloride and benefit the public.

Preparation method of imidazoline derivative

The invention discloses a preparation method of an imidazoline derivative, and particularly relates to a preparation method of tizanidine hydrochloride. The preparation method of the imidazoline derivative comprises the following steps: A, taking a compound II and a compound III, reacting the compound II and the compound III in an organic solvent in the presence of a dehydrating agent, alkalizingand filtering the reaction product to obtain a compound IV; B, hydrolyzing the compound IV obtained in the step A as a raw material to obtain tizanidine shown by formula V; and C, preparing the tizanidine hydrochloride shown in formula I from the tizanidine obtained in the step B as a raw material. The method has high yield and purity simultaneously, is simple and convenient to operate, high in production efficiency, environmentally friendly and safe, is suitable for industrial mass production, and has wide market application prospect.