173547-44-9 Usage
Uses
Used in Pharmaceutical Industry:
3-Amino-1-propanol-d4 is used as a complexing agent for Mefenamic acid, a nonsteroidal anti-inflammatory drug (NSAID). The complex formed between 3-Amino-1-propanol-d4 and Mefenamic acid improves the drug's transdermal permeation properties, allowing for better absorption through the skin and potentially enhancing the drug's efficacy and bioavailability.
Used in Research and Development:
3-Amino-1-propanol-d4 can be utilized in various research applications, particularly in the field of chemistry and biochemistry. Its deuterated nature makes it a valuable tool for studying the behavior of molecules in different environments and under various conditions. It can be used in nuclear magnetic resonance (NMR) spectroscopy to investigate the structure and dynamics of molecular interactions.
Used in Drug Delivery Systems:
Similar to its application in the pharmaceutical industry, 3-Amino-1-propanol-d4 can be employed in the development of drug delivery systems. Its ability to form complexes with other molecules can be leveraged to improve the solubility, stability, and bioavailability of various drugs, potentially leading to more effective treatments for a range of medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 173547-44-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,5,4 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 173547-44:
(8*1)+(7*7)+(6*3)+(5*5)+(4*4)+(3*7)+(2*4)+(1*4)=149
149 % 10 = 9
So 173547-44-9 is a valid CAS Registry Number.
173547-44-9Relevant academic research and scientific papers
Walsh,Shulman-Roskes,Anderson,Chang,Ludeman
, p. 1193 - 1198 (1995)
3-Hydroxypropionitrile was subjected to a base-catalyzed exchange reaction in D2O which provided 2,2-dideuterio-3-deuteroxypropionitrile (DOCH2CD2CN) in 70% yield. Reduction of the nitrile with LIAlD4 gave 3-amino-2,2,3,3- tetradeuteriopropan-1-ol (HOCH2CD2CD2NH2) in a crude yield of 71%. Reaction of this intermediate with N,N-bis (2-chloroethyl)phosphoramidic dichloride [Cl2P(O)N(CH2CH2Cl)2] followed by the combination of those chromatography fractions which contained only pure material gave cyclophosphamide-4,4,5,5-d4 as a white oil in 13% yield. A portion of this oil was converted to the monohydrate by the addition of water (1.1 equivalents) and crystallization from ether/petroleum ether (628 yield). For the hydrate, MS analyses gave an average mole percent enrichment (with average deviation over 5 determinations) of 89.1 ± 0.5% d4.
Labeled oxazaphosphorines for applications in mass spectrometry studies. 2. Synthesis of deuterium-labeled 2-dechloroethylcyclophosphamides and 2- and 3-dechloroethylifosfamides
Springer, James B.,Colvin, O. Michael,Ludeman, Susan M.
, p. 110 - 114 (2014/03/21)
The prodrugs cyclophosphamide (CP) and ifosfamide (IF) each metabolize to an active alkylating agent through a cytochrome P450-mediated oxidation at the C-4 position. Competing with this activation pathway are enzymatic oxidations at the exocyclic α and α
