173549-09-2

Upstream product

• 93-61-8 N-methyl-N-phenylformamide 
• 135279-44-6 2-(4-chlorophenyl)-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one 
• 135279-10-6 4-oxo-4,5,6,7-tetrahydrothieno<2,3-b>thiepin-5-acetonitrile 
• 135278-97-6 4-oxo-4,5,6,7-tetrahydrothieno<2,3-b>thiepin-5-acetic acid 
• 135279-42-4 2-(4-chlorophenyl)-4,4a,5,6-tetrahydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one 

Downstream Products

• 173549-06-9 2-(4-chlorophenyl)-9-cyano-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one 

Relevant academic research and scientific papers

Synthesis and structure-activity analysis of 2-(4-chlorophenyl)-5,6-dihydrothienothiepinopyridazin-3(2H)-ones as ligands for benzodiazepine receptors

A series of 2-(4-chlorophenyl)-5,6-dihydrothienothiepinopyridazin-3(2H)-ones were synthesized and evaluated in vitro for their affinity toward benzodiazepine receptors (BZRs) in rats and for their intrinsic efficacy in the augmentation of the γ-aminobutyric acid (GABA)-induced chloride currents in the dissociated frog sensory neurons.Compounds in wich the 9-position of the condensed-ring system was substituted with alkyl group or bromine had a high affinity toward BZRs.The substituents at the same position also influenced significantly the GABA-induced chloride currents.As the result, 9-alkyl and 9-bromo substutuents would interact with the lipophilic area of BZRs.A series of 2-(4-chlorophenyl)-5,6-dihydrothienothiepinopyridazin-3(2H)-ones exhibited partial and full agonistic activities toward BZRs. benzodiazepine receptor / γ-aminobutyric acid / partial agonist / full agonist / structure activity relationship