173589-92-9Relevant articles and documents
An improved synthesis of levofloxacin
Kang, Soon Bang,Park, Seonhee,Kim, Yong Hae,Kim, Youseung
, p. 137 - 145 (2007/10/03)
The benzoxazinecarboxylic acid (8), a precursor of levofloxacin (1), was prepared from (S)-2-amino-l-propanol (2) in 4 steps in good overall yield. The synthesis is characterized by one pot construction of 8 from the useful benzoylacrylates (7) which are effectively prepared in three steps. The key intermediates (7) were obtained from 2-nitrobenzoyl derivative (6a) and 2-fluorobenzoyl derivative (6b) through acylation of the acrylates (5), respectively.