173590-99-3Relevant academic research and scientific papers
1-[Styryl]- and 1-[2'-(heteroaryl)-ethenyl]-isoquinoline derivatives, a process for preparing them as well as medicaments containing them and the use of them
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, (2008/06/13)
A subject-matter of the invention are 1-[styryl]- and 1-[2'-(heteroaryl)-ethenyl]-isoquinoline derivatives having the formula wherein nis 1, 2, 3 or 4, Rwhich represent(s) hydrogen, C1 7-alkyl, C1 7-alkoxy or hydroxy, or two substituents R form together a C1 7-alkylenedioxy group attached to two adjacent ring carbon atoms, R1represents hydrogen or C1 7-alkyl and Arstands for an aryl or heteroaryl group containing one or two oxygen, nitrogen and/or sulfur atom(s), optionally carrying one or more substituent(s) selected from halogen, trihalomethyl, hydroxy, C1 7-alkyl, C1 7-alkoxy, C1 7-alkylenedioxy (attached to two adjacent ring carbon atoms), cyano, nitro, amino, mono- and di-(C1 7-alkyl)-amino, as well as acid addition salts thereof. Furthermore the invention is concerned with a process for preparing these compounds as well as medicaments containing them and the use both of the novel and of the known compounds for preparing medicaments having an anxiolytic effect.
