173600-13-0

Basic information

• Product Name: 1-ISOBUTYLINDAZOLE-3-CARBOXYLIC ACID
• Synonyms: 1-ISOBUTYLINDAZOLE-3-CARBOXYLIC ACID
• CAS NO: 173600-13-0
• Molecular Formula: C₁₂H₁₄N₂O₂
• Molecular Weight: 218.25
• Mol File: 173600-13-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-ISOBUTYLINDAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ISOBUTYLINDAZOLE-3-CARBOXYLIC ACID(173600-13-0)
• EPA Substance Registry System: 1-ISOBUTYLINDAZOLE-3-CARBOXYLIC ACID(173600-13-0)

Safety Data

• Hazardous Substances Data: 173600-13-0(Hazardous Substances Data)

Upstream product

• 173600-04-9 1-Isobutyl-1H-indazole-3-carboxylic acid methyl ester 
• 43120-28-1 methyl 1H-indazole-3-carboxylate 

Relevant articles and documents

Indazole derivatives having monocyclic amine

An indazole compound having the formula (I): wherein: R1 is hydrogen, C1 -C6 alkyl, C3 -C6 alkenyl or C3 -C6 cycloalkyl; Q is carbonyl, thiocarbonyl or methylene; and R2 is a group of the formula (II) or (IV); STR1 wherein R1 is C1 -C6 alkyl, C3 -C6 alkenyl or benzyl, of which a phenyl group thereof is optionally mono- or di-substituted by the same or different halogen or methoxy; m is 0 to 2; n and o is 1 or 2. The compound exhibits 5-HT4 receptor agonist activity.

Development of potent serotonin-3 (5-HT3) receptor antagonists. II. Structure-activity relationships of N-(1-benzyl-4-methylhexahydro-1H-1,4- diazepin-6-yl)carboxamides

Our studies on 4-amino-5-chloro-2-ethoxybenzamides led to the discovery that the N-(1,4-dimethylhexahydro-1H-1,4-diazepin-6-yl)benzamide 9 and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 10 are potent serotonin-3 (5-HT3) receptor antagonists. Structure-activity relationship (SAR) studies on the influence of the aromatic nucleus of 9 and 10 upon inhibition of the von Bezold-Jarisch reflex in rats are described. Heteroaromatic rings such as pyrrole, thiophene, furan, pyridine, pyridaziae, 1,2-benzisoxazole, indole, quinoline, and isoquinoline rings showed weak 5-HT3 receptor antagonistic activity. Within this series, use of the 1H-indazole ring as an aromatic moiety led to a substantial increase of the activity; the 1H- indazolylcarboxamides 54, 57, 97, and 102 showed potent 5-HT3 receptor antagonistic activity. The optimal compound identified via extensive SAR studies was N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole- 3-carboxamide (54), whose effect was superior to that of the corresponding benzamide 10 and essentially equipotent to those of ondansetron (1) and granisetron (4).