17364-19-1

Basic information

• Product Name: ()-(7-hydroxy-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacosyl)trimethylammonium 4-oxide
• Synonyms: (1)-(7-Hydroxy-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacosyl)trimethylammonium 4-oxide; 2-hydroxy-3-(octadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
• CAS NO: 17364-19-1
• Molecular Formula: C₂₆H₅₄NO₇P
• Molecular Weight: 523.6832
• EINECS: 241-397-2
• Mol File: 17364-19-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ()-(7-hydroxy-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacosyl)trimethylammonium 4-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: ()-(7-hydroxy-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacosyl)trimethylammonium 4-oxide(17364-19-1)
• EPA Substance Registry System: ()-(7-hydroxy-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacosyl)trimethylammonium 4-oxide(17364-19-1)

Safety Data

• Hazardous Substances Data: 17364-19-1(Hazardous Substances Data)

Usage

General Description

-(7-hydroxy-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacosyl)trimethylammonium 4-oxide is a long, complex chemical compound that contains a phosphorus atom and a trimethylammonium group. The compound also includes a hydroxy group and a series of oxygen atoms in its molecular structure. This chemical is likely to have surfactant properties due to its long hydrophobic tail and polar head group, making it potentially useful for applications in emulsification and detergency. Additionally, the presence of the trimethylammonium group suggests that it may have antimicrobial properties, making it potentially useful in disinfectant or antiseptic formulations. Further research and testing are needed to fully understand the potential uses and properties of this chemical compound.

Upstream product

• 18679-03-3 1-stearoyl-2-O-benzyl-rac-glycerol 
• 34688-34-1 glycerolcholine phosphate 
• 57-11-4 stearic acid 
• 111-63-7 vinyl stearate 
• 112-76-5 Stearoyl chloride 
• 17450-32-7 1-octadecanoyl-1H-imidazole 
• 816-94-4 {2-[(2,3-bis-stearoyloxy-propoxy)-hydroxy-phosphoryloxy]-ethyl}-trimethyl-ammonium betaine 
• 18678-96-1 rac.-1-Stearoyl-glycerin-benzylether-⁽²⁾-phosphorsaeure-⁽³⁾-monocholinester 

Downstream Products

• 18892-74-5 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine 
• 6753-53-3 1-octadecanoyl-2-[cis-9,12]-octadecadienoyl-glycero-3-phosphocholine 

Relevant articles and documents

Method for synthesizing platelet activating factor (PAF) analog

The invention discloses a method for synthesizing a platelet activating factor (PAF) analog which is of a formula shown in the specification from glyceryl phosphoryl choline as a raw material according to scheme of the following three steps of reactions: 1, enabling glyceryl phosphoryl choline, a hydroxyl activator and an aliphatic hydrocarbon carbonyl compound to react to generate an intermediate1; 2, enabling the intermediate 1 to react with cyclic anhydride to generate an intermediate 2; and 3, enabling the intermediate 2 to react with nitrophenol and a condensing agent to generate a product, namely the PAF analog. In the step 1, the glyceryl phosphoryl choline is adopted as a reaction initializing raw material, and a series of PAF analogs can be derived; in the step 2, a catalyst is additionally used, so that the yield can be increased; and in the step 3, a condensing agent which is gentle in reaction condition is selected, so that reaction steps can be reduced, an acyl chloride intermediate which is good in corrosiveness and easy to dehydrate is not generated, and equipment consumption can be reduced.

Process for the production of phospholipids

A new enzymatic process for preparing 1,2-diacylated phospholipids using an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation. The process of the invention further relates to a process for the production of 1-acyl-2-lyso-glycerophospholipid, preferably 2-lyso-PC by reacting glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of a sn-1 specific phospholipase (PLA1 or PLA1,2) and a solvent, in a microaqueous medium.

13C NMR Spectra of 1-Stearoyl-2-Linoleyl-sn-Glycero-3-Phosphorylcholine and 1-Stearoyl-2-Arachidonoyl-sn-Glycero-3-Phosphorylcholine in CDCl3 Solution and in Sonicated Dispersions in 2H2O

Two mixed-acid lecithins: 1-stearoyl-2-linoleyl-sn-glycero-3-phosphorylcholine (SLL) and 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (SAL) have been synthesized by phospholipase A2 digestion of 1,2-distearoyl-sn-glycero-3-phosphorylcholine (DSL), followed by reacylation of the lysolecithin with the desired fatty acid anhydride. 13C (25.2 MHz) NMR spectra of SLL and SAL in CDCl3 solution and in sonicated dispersions in 2H2O have been obtained.Complete spectral assignments are reported for the two molecules in both systems. 13C nuclear spin-lattice relaxation times (T1) af SLL and SAL in sonicated aqueous dispersions have also been measured.Relaxation rate profiles as a function of the chain segment position are in general agreement with those recently obtained from 2H NMR for similar systems.