173666-23-4

Basic information

• Product Name: 3-(benzyloxyMethyl)acrylonitrile
• Synonyms: 3-(benzyloxyMethyl)acrylonitrile
• CAS NO: 173666-23-4
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.21114
• Mol File: 173666-23-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(benzyloxyMethyl)acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(benzyloxyMethyl)acrylonitrile(173666-23-4)
• EPA Substance Registry System: 3-(benzyloxyMethyl)acrylonitrile(173666-23-4)

Safety Data

• Hazardous Substances Data: 173666-23-4(Hazardous Substances Data)

Upstream product

• 60656-87-3 benzyloxyacetoaldehyde 
• 137618-52-1 4-(benzyloxy)-3-hydroxybutanenitrile 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 

Downstream Products

• 1206540-43-3 ethyl 3-(benzyloxymethyl)-4-cyano-2,2-difluorobutanoate 
• 1274887-23-8 C₂₅H₂₅F₃N₄O₂ 
• 1274885-07-2 N-[3-methoxy-5-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-5-[(phenylmethoxy)methyl]-1H-pyrazol-3-amine 
• 1274887-19-2 C₁₇H₂₀N₄O 

Relevant articles and documents

Substituted N-Phenyl-1-(4-Pyridinyl)-1H-Pyrazol-3-Amines

The present invention relates to N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amine derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to formula (I) Wherein R1, R2, R3, R4, R5, R6 have the meaning defined in the claims. The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

Synthesis of 4-substituted 3,3-difluoropiperidines

Synthetic strategies toward 4-substituted 3,3-difluoropiperidines were evaluated. 4-Alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines were synthesized via 1,4-addition of ethyl bromodifluoroacetate to 3-substituted acrylonitriles in the presence o