173679-09-9Relevant articles and documents
Synthesis and Docking Study of N-(Cinnamoyl)- N′-(substituted)acryloyl Hydrazide Derivatives Containing Pyridinium Moieties as a Novel Class of Filamentous Temperature-Sensitive Protein Z Inhibitors against the Intractable Xanthomonas oryzae pv. oryzae Infections in Rice
Feng, Yu-Mei,Li, Zhong,Liu, Li-Wei,Ma, Hao-Dong,Qi, Pu-Ying,Shao, Wu-Bin,Wang, Pei-Yi,Wang, Yi,Wu, Zhi-Bing,Yang, Song,Zhou, Xiang
, p. 8132 - 8142 (2020)
Xanthomonas oryzae pv. oryzae (Xoo) is an offensive phytopathogen that can invade a wide range of plant hosts to develop bacterial diseases, including the well-known rice bacterial leaf blight. However, few agrochemicals have been identified to effectively prevent and eliminate Xoo-induced diseases. Thus, designing novel antibacterial compounds on the basis of the potential targets from Xoo may lead to the discovery of highly efficient and innovative anti-Xoo agents. Filamentous temperature-sensitive protein Z (FtsZ), an important functional protein in the progression of cell division, has been widely reported and exploited as a target for creating antibacterial drugs in the field of medicine. Therefore, the fabrication of innovative frameworks targeting XooFtsZ may be an effective method for managing bacterial leaf blight diseases via blocking the binary division and reproduction of Xoo. As such, a series of novel N-(cinnamoyl)-N′-(substituted)acryloyl hydrazide derivatives containing pyridinium moieties were designed, and the anti-Xoo activity was determined. The bioassay results showed that compound A7 had excellent anti-Xoo activity (EC50 = 0.99 mg L-1) in vitro and distinct curative activity (63.2% at 200 mg L-1) in vivo. Further studies revealed that these designed compounds were XooFtsZ inhibitors, validating by the reduced GTPase activity of recombinant XooFtsZ, the nonfilamentous XooFtsZ assembly observed in the TEM images, and the prolonged Xoo cells from the fluorescence patterns. Computational docking studies showed that compound A7 had strong interactions with ASN34, GLN193, and GLN197 residues located in the α helix regions of XooFtsZ. The present study demonstrates the developed FtsZ inhibitors can serve as agents to control Xoo-induced infections.
Pyridinium salt-containing N-(cinnamoyl)-N'-(substituted) propyl hydrazide compound, preparation method and application thereof
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Paragraph 0052-0053, (2020/07/21)
The invention relates to a pyridinium salt-containing N-(cinnamoyl)-N'-(substituted) propyl hydrazide compound, a preparation method and application thereof. The compound has a structure shown as general formula (I); the compound has a good inhibition effect on pathogenic bacteria and fungi, and has good inhibition effects on Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, cucumber bacterial blight bacteria,konjak bacterial blight bacteria, Xanthomonas axonopodis pv. Citri, botryosphaeria dothidea, Clavibacter michiganensis subsp.michiganensis, pseudomonas syringae pv. actinidiae, applecanker bacteria, cucumber botrytis cinerea, fusarium oxysporum, sclerotinia sclerotiorum, gibberella zeae, phytophthora infestans, P. cinnamomi and the like.
3,6-Bis(2-arylethenyl)-1,2,4,5-tetrazines - Synthesis, LC Properties and Photochemistry
Lifka, Thorsten,Meier, H.
, p. 641 - 646 (2007/10/03)
The (E,E)-3,6-bis(2-arylethenyl)-1,2,4,5-tetrazines 8 were prepared in a synthetic sequencve starting with aromatic aldehydes 1 and cinnamic acids 2, respectively (Scheme 1).The rod-like conjugated molecules represent clamitic mesogens as well as extended chromophores.Hence, we investigated the formation of liquid crystals, achieved by the introduction of long flexlible side chains, and the photochemical behaviour that is characterized by the fragmentation of the central ring (Scheme 3).
