17368-40-0Relevant academic research and scientific papers
Synthetic method for drug intermediate 5-pregnene-16alpha,17alpha-epoxy-3beta-ol-20-one
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Paragraph 0012; 0014-0025, (2018/07/30)
The invention discloses a synthetic method for the drug intermediate 5-pregnene-16alpha,17alpha-epoxy-3beta-ol-20-one. The synthetic method comprises the following steps: adding 5-pregnene-16-hydroxy-17-bromo-3-methoxy-20-one and a sodium chloride solution into a reaction vessel, raising the temperature of the obtained solution, controlling a stirring speed, adding lead dioxide and a dodecanol solution and continuing a reaction; and then adding zinc benzoate powder, raising the temperature of the obtained solution, continuing the reaction, carrying out cooling, subjecting the solution to standing so as to realize layering of the solution, carrying out washing with a potassium sulfate solution, carrying out washing with a trichlorotoluene solution, then carrying out recrystallization in a triethylene glycol monomethyl ether solution, and then carrying out dehydration with a dehydrating agent to obtain finished 5-pregnene-16alpha,17alpha-epoxy-3beta-ol-20-one.
