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17376-42-0

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17376-42-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 17376-42-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,3,7 and 6 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 17376-42:
(7*1)+(6*7)+(5*3)+(4*7)+(3*6)+(2*4)+(1*2)=120
120 % 10 = 0
So 17376-42-0 is a valid CAS Registry Number.

17376-42-0Downstream Products

17376-42-0Relevant articles and documents

Nucleofugality hierarchy, in the aminolysis reaction of 4-cyanophenyl 4-nitrophenyl carbonate and thionocarbonate. Experimental and theoretical study

Aliaga, Margarita E.,Cornejo, Patricio,Montecinos, Rodrigo,Pavez, Paulina,Santos, José G.

, p. 11495 - 11505 (2021/07/12)

Nucleophilic substitution reactions of the title compounds have been investigated with a series of secondary alicyclic amines in several solvents. The solvent, amine, and electrophilic group effects on kinetics, mechanism and nucleofugality hierarchy are discussed from experimental and theoretical studies. These studies show the mechanistic dependence on the solvent polarity; the theoretical results indicate that the relative polarization of the reactive centres (CO and CS) and the stabilization of the nucleofuges are the main factors in the control of the product distribution.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

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Paragraph 0456, (2017/03/28)

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

Structure-reactivity correlations in the aminolysis of aryl chloroformates

Castro, Enrique A.,Ruiz, Mara G.,Santos, Jos G.

, p. 281 - 287 (2007/10/03)

The reactions of a series of secondary alicyclic amines with 4-methylphenyl and 4-methoxyphenyl chloroformates are subjected to a kinetic investigation in water, at 25.0°C, ionic strength 0.2 M (KCI). Under amine excess, pseudo-first-order rate coefficients (kobs) are found for all reactions. Plots of kobs vs [NH] (NH is the free amine) are linear, with the slope (kN) pH independent, except the reactions of l-(2-hydroxyethyl)piperazine with both substrates at pH 6.2-7.3. The Broensted-type plots for the kN values for the aminolysis of both chloroformates are linear, with slopes ca. 0.3, which is consistent with rate-determining formation of a zwitterionic tetrahedral intermediate (T±). With the PKa and log kN data for the present reactions, together with those for the same aminolysis of phenyl and 4-nitrophenyl chloroformates, two dual parametric equations are found for log kN as a function of pKa of the nucleophile, Hammett sigma of the "nonleaving" group, and pKa of the "nonleaving" group, with coefficients βN = 0.3, ρnlg = 0.7, and βnlg = -0.2, respectively.

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