173838-41-0Relevant articles and documents
Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens
Denis, Alexis,Agouridas, Constantin,Auger, Jean-Michel,Benedetti, Yannick,Bonnefoy, Alain,Bretin, Francois,Chantot, Jean-Francois,Dussarat, Arlette,Fromentin, Claude,Gouin D'Ambrieres, Solange,Lachaud, Sylvette,Laurin, Patrick,Le Martret, Odile,Loyau, Veronique,Tessot, Nicole,Pejac, Jean-Marie,Perron, Sebastien
, p. 3075 - 3080 (2007/10/03)
In the search for new ketolides with improved activities against erythromycin-resistant S. pneumoniae and H. influenzae we synthesized a new 11,12 carbamate ketolide substituted by an imidazo-pyridyl side chain: HMR 3647. This compound demonstrated a potent activity against erythromycin susceptible and resistant pathogens, including penicillin G/erythromycin A-resistant S. pneumoniae and H. influenzae. In vivo, HMR 3647 displayed good pharmacokinetic parameters (Cmax = 2.9 μg/ml, bioavailability = 49%, AUC0-8 = 17.2 μg.h/l, t( 1/2 )= lh) and was shown to have a high therapeutic efficacy in mice infected by various respiratory pathogens, including multi-resistant S. pneumoniae and Gram negative bacteria such as H. influenzae. HMR 3647 appears to be a very promising agent for the treatment of respiratory infections and is currently in clinical trials.
Erythromycin compounds
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, (2008/06/13)
An erythromycin compound of Formula I or its non-toxic acid addition salt having antibiotic activity.